4M8T

RSK2 T493M C-Terminal Kinase Domain in complex with 3-(3-(1H-pyrazol-4-yl)phenyl)-2-cyanoacrylamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ribosomal protein S6 kinase alpha-3	polymer	355	40097.6	1	UniProt (P18654) Pfam (PF00069)	Mus musculus (mouse)	S6K-alpha-3, 90 kDa ribosomal protein S6 kinase 3, p90-RSK 3, p90RSK3, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, Ribosomal S6 kinase 2, RSK-2, pp90RSK2
2	B (A)	(2E)-2-cyano-3-[3-(1H-pyrazol-4-yl)phenyl]prop-2-enamide	non-polymer		238.2	1	Chemie (RMM)
3	C (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A: 399 - 740 (UniProt: P18654)

PDB	External Database	Details
Ala 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
Val 393	-	expression tag
Asp 394	-	expression tag
Asp 395	-	expression tag
Asp 396	-	expression tag
Asp 397	-	expression tag
Lys 398	-	expression tag
Met 493	Thr 494	engineered mutation
Glu 591	Lys 592	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40097.6
Non-Polymers*	Number of molecules	2
	Total formula weight	261.2
All*	Total formula weight	40358.9

*Water molecules are not included.