4OO9
Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant
Summary for 4OO9
Entry DOI | 10.2210/pdb4oo9/pdb |
Descriptor | Metabotropic glutamate receptor 5, Lysozyme, Metabotropic glutamate receptor 5 chimera, OLEIC ACID, Mavoglurant, ... (5 entities in total) |
Functional Keywords | 7tm, receptor, g-protein, cysteine-s-acetamide, membrane protein |
Biological source | Homo sapiens (human, T4 phage, human) More |
Cellular location | Cell membrane {ECO:0000269|PubMed:7908515, ECO:0000269|Ref: P41594 |
Total number of polymer chains | 1 |
Total formula weight | 51555.11 |
Authors | Dore, A.S.,Okrasa, K.,Patel, J.C.,Serrano-Vega, M.,Bennett, K.,Cooke, R.M.,Errey, J.C.,Jazayeri, A.,Khan, S.,Tehan, B.,Weir, M.,Wiggin, G.R.,Marshall, F.H. (deposition date: 2014-01-31, release date: 2014-07-02, Last modification date: 2023-09-20) |
Primary citation | Dore, A.S.,Okrasa, K.,Patel, J.C.,Serrano-Vega, M.,Bennett, K.,Cooke, R.M.,Errey, J.C.,Jazayeri, A.,Khan, S.,Tehan, B.,Weir, M.,Wiggin, G.R.,Marshall, F.H. Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature, 511:557-562, 2014 Cited by PubMed: 25042998DOI: 10.1038/nature13396 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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