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PDB: 102 件
5MTM
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BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
3RIM
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BU of 3rim by Molmil
Crystal structure of mycobacterium tuberculosis Transketolase (Rv1449c)
分子名称: GLYCEROL, MAGNESIUM ION, THIAMINE DIPHOSPHATE, ...
著者Pojer, F, Fullam, E, Jones, T.A, Cole, S.T.
登録日2011-04-14
公開日2012-02-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Open Biol, 2, 2012
2F9A
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BU of 2f9a by Molmil
HMG-CoA synthase from Brassica juncea in complex with F-244
分子名称: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, 3-Hydroxy-3-methylglutaryl coenzyme A synthase 1
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-05
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
4ZDA
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BU of 4zda by Molmil
Crystal structure of isocitrate dehydrogenase in complex with isocitrate and Mn from M. smegmatis
分子名称: ISOCITRIC ACID, Isocitrate dehydrogenase (NADP) Icd2, MANGANESE (II) ION
著者Pojer, F, Murima, P, McKinney, J.D.
登録日2015-04-17
公開日2016-06-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献crystal structure of isocitrate dehydrogenase in complex with isocitrate and Mn from M. smegmatis
To Be Published
2F82
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BU of 2f82 by Molmil
HMG-CoA synthase from Brassica juncea in the apo-form
分子名称: HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-01
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA3
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BU of 2fa3 by Molmil
HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.
分子名称: ACETYL COENZYME *A, HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-06
公開日2006-07-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
4BGE
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BU of 4bge by Molmil
Crystal structure of InhA(S94A) mutant in complex with pyridomycin
分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], Pyridomycin
著者Pojer, F, Hartkoorn, R.C, Cole, S.T.
登録日2013-03-26
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Nat. Chem. Biol., 10, 2014
4BGI
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BU of 4bgi by Molmil
Crystal structure of InhA(S94A) mutant in complex with OH-141
分子名称: 3-hydroxy-N-[(2R,5R,6S,9S,10S,11R)-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-2-(propan-2-yl)-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododecan-6-yl]pyridine-2-carboxamide, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Pojer, F, Hartkoorn, R.C, Cole, S.T.
登録日2013-03-27
公開日2013-12-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA.
Nat. Chem. Biol., 10, 2014
2FA0
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BU of 2fa0 by Molmil
HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA
分子名称: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, HMG-CoA synthase
著者Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
登録日2005-12-06
公開日2006-07-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2Q6K
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BU of 2q6k by Molmil
SalL with adenosine
分子名称: ADENOSINE, DI(HYDROXYETHYL)ETHER, chlorinase
著者Pojer, F, Noel, J.P.
登録日2007-06-05
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Nat.Chem.Biol., 4, 2008
2Q6L
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BU of 2q6l by Molmil
SalL double mutant Y70T/G131S with CLDA and L-MET
分子名称: 5'-CHLORO-5'-DEOXYADENOSINE, Hypothetical protein, METHIONINE
著者Pojer, F, Noel, J.P.
登録日2007-06-05
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Discovery and characterization of a marine bacterial SAM-dependent chlorinase
Nat.Chem.Biol., 4, 2008
4DRE
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BU of 4dre by Molmil
Mycobacterium tuberculosis InhA in complex with NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH]
著者Pojer, F, Hartkoorn, R.C, Boy, S, Cole, S.T.
登録日2012-02-17
公開日2012-10-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.
EMBO Mol Med, 4, 2012
4DTI
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BU of 4dti by Molmil
Mycobacterium tuberculosis InhA-S94A mutant in complex with NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH]
著者Pojer, F, Hartkoorn, R.C, Boy, S, Cole, S.T.
登録日2012-02-21
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.
EMBO Mol Med, 4, 2012
4DQU
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BU of 4dqu by Molmil
Mycobacterium tuberculosis InhA-D148G mutant in complex with NADH
分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Enoyl-[acyl-carrier-protein] reductase [NADH]
著者Pojer, F, Hartkoorn, R.C, Boy, S, Cole, S.T.
登録日2012-02-16
公開日2012-10-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.
EMBO Mol Med, 4, 2012
6O03
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BU of 6o03 by Molmil
Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC17)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL
To Be Published
8AQW
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BU of 8aqw by Molmil
BA.4/5 SARS-CoV-2 Spike bound to mouse ACE2 (local)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, ...
著者Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E.
登録日2022-08-13
公開日2023-03-15
最終更新日2023-04-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Plos Pathog., 19, 2023
6TLC
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BU of 6tlc by Molmil
Unphosphorylated human STAT3 in complex with MS3-6 monobody
分子名称: Monobody, Signal transducer and activator of transcription 3
著者La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Nat Commun, 11, 2020
6TWB
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BU of 6twb by Molmil
Crystal Structure of the Catalytic Domain of Coagulation Factor XIa in Complex with Double Bridged Peptide F19
分子名称: AMMONIUM ION, Coagulation factor XI, Double Bridged Peptide F19
著者Kong, X.D, Pojer, F, Heinis, C.
登録日2020-01-13
公開日2020-05-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献De novo development of proteolytically resistant therapeutic peptides for oral administration.
Nat Biomed Eng, 4, 2020
8RND
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BU of 8rnd by Molmil
Cathepsin S in complex with NNPI-C10 inhibitor
分子名称: 1,2-ETHANEDIOL, Cathepsin S, DI(HYDROXYETHYL)ETHER, ...
著者Petruzzella, A, Lau, K, Pojer, F, Oricchio, E.
登録日2024-01-09
公開日2024-06-05
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
Nat.Chem.Biol., 2024
7QUV
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BU of 7quv by Molmil
Crystal structure of human Calprotectin (S100A8/S100A9) in complex with Peptide 3
分子名称: 1,2-ETHANEDIOL, 4-methanoyl-2-(6-oxidanyl-3-oxidanylidene-4~{H}-xanthen-9-yl)benzoic acid, AMINO GROUP, ...
著者Diaz-Perlas, C, Heinis, C, Pojer, F, Lau, K.
登録日2022-01-19
公開日2023-02-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays.
Nat Commun, 14, 2023
6TWC
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BU of 6twc by Molmil
Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Double Bridged Peptide F21
分子名称: ACETONE, Coagulation factor XI, Double Bridged Peptide F21
著者Kong, X.D, Pojer, F, Heinis, C.
登録日2020-01-13
公開日2020-05-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献De novo development of proteolytically resistant therapeutic peptides for oral administration.
Nat Biomed Eng, 4, 2020
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
分子名称: Tyrosine-protein kinase BTK, rF10 repebody
著者Duarte, D.P, Pojer, F, Hantschel, O.
登録日2018-10-04
公開日2020-05-20
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
6O02
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BU of 6o02 by Molmil
Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC3)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.953 Å)
主引用文献Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
To Be Published
3BWN
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BU of 3bwn by Molmil
L-tryptophan aminotransferase
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, L-tryptophan aminotransferase, PHENYLALANINE, ...
著者Ferrer, J.-L, Noel, J.P, Pojer, F, Bowman, M, Chory, J, Tao, Y.
登録日2008-01-10
公開日2008-04-29
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants
Cell(Cambridge,Mass.), 133, 2008

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件を2024-07-03に公開中

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