6TWC

Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Double Bridged Peptide F21

Summary for 6TWC

• Entry DOI: 10.2210/pdb6twc/pdb
• Descriptor: Coagulation factor XI, Double Bridged Peptide F21, ACETONE, ... (4 entities in total)
• Functional Keywords: protease, coagulation factors, inhibitor, double bridged peptide, phage display, blood clotting
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 31304.73

Authors

Kong, X.D.,Pojer, F.,Heinis, C. (deposition date: 2020-01-13, release date: 2020-05-20, Last modification date: 2024-01-24)

• Primary citation: Kong, X.D.,Moriya, J.,Carle, V.,Pojer, F.,Abriata, L.A.,Deyle, K.,Heinis, C.; De novo development of proteolytically resistant therapeutic peptides for oral administration.; Nat Biomed Eng, 4:560-571, 2020; PubMed: 32393891; DOI: 10.1038/s41551-020-0556-3

Experimental method

X-RAY DIFFRACTION (2.86 Å)