8RND

Cathepsin S in complex with NNPI-C10 inhibitor

This is a non-PDB format compatible entry.

Summary for 8RND

• Entry DOI: 10.2210/pdb8rnd/pdb
• Related: 8PI3
• Descriptor: Cathepsin S, NNPI-C10 inhibitor, 1,2-ETHANEDIOL, ... (8 entities in total)
• Functional Keywords: protease, inhibitor, complex, cathepsin, oncoprotein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 26558.85

Authors

Petruzzella, A.,Lau, K.,Pojer, F.,Oricchio, E. (deposition date: 2024-01-09, release date: 2024-06-05, Last modification date: 2024-06-12)

• Primary citation: Petruzzella, A.,Bruand, M.,Santamaria-Martinez, A.,Katanayeva, N.,Reymond, L.,Wehrle, S.,Georgeon, S.,Inel, D.,van Dalen, F.J.,Viertl, D.,Lau, K.,Pojer, F.,Schottelius, M.,Zoete, V.,Verdoes, M.,Arber, C.,Correia, B.E.,Oricchio, E.; Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.; Nat.Chem.Biol., 2024; PubMed: 38811854; DOI: 10.1038/s41589-024-01627-z

Experimental method

X-RAY DIFFRACTION (1.56 Å)