6HTF

Crystal structure of human Btk SH2 domain bound to rF10 repebody

Summary for 6HTF

Entry DOI	10.2210/pdb6htf/pdb
Descriptor	Tyrosine-protein kinase BTK, rF10 repebody (3 entities in total)
Functional Keywords	repebody, sh2 domain, btk, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	44346.08
Authors	Duarte, D.P.,Pojer, F.,Hantschel, O. (deposition date: 2018-10-04, release date: 2020-05-20, Last modification date: 2024-01-24)
Primary citation	Duarte, D.P.,Lamontanara, A.J.,La Sala, G.,Jeong, S.,Sohn, Y.K.,Panjkovich, A.,Georgeon, S.,Kukenshoner, T.,Marcaida, M.J.,Pojer, F.,De Vivo, M.,Svergun, D.,Kim, H.S.,Dal Peraro, M.,Hantschel, O. Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11:2319-2319, 2020 Cited by PubMed: 32385234 DOI: 10.1038/s41467-020-16128-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.102 Å)

Structure validation