6TLC

Unphosphorylated human STAT3 in complex with MS3-6 monobody

Summary for 6TLC

Entry DOI	10.2210/pdb6tlc/pdb
Descriptor	Signal transducer and activator of transcription 3, Monobody (3 entities in total)
Functional Keywords	inhibitor, complex, stat3, monobody, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	156752.86
Authors	La Sala, G.,Lau, K.,Reynaud, A.,Pojer, F.,Hantschel, O. (deposition date: 2019-12-02, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	La Sala, G.,Michiels, C.,Kukenshoner, T.,Brandstoetter, T.,Maurer, B.,Koide, A.,Lau, K.,Pojer, F.,Koide, S.,Sexl, V.,Dumoutier, L.,Hantschel, O. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat Commun, 11:4115-4115, 2020 Cited by PubMed: 32807795 DOI: 10.1038/s41467-020-17920-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation