6TLC
Unphosphorylated human STAT3 in complex with MS3-6 monobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0007165 | biological_process | signal transduction |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0007165 | biological_process | signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP |
| Chain | Residue | Details |
| D | GLY37-PRO44 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:28065600 |
| Chain | Residue | Details |
| B | LYS601 | |
| B | LYS615 | |
| B | LYS631 | |
| A | LYS601 | |
| A | LYS615 | |
| A | LYS631 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by TYK2 => ECO:0000269|PubMed:29162862 |
| Chain | Residue | Details |
| B | TYR640 | |
| A | TYR640 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:15653507, ECO:0000269|PubMed:28065600 |
| Chain | Residue | Details |
| B | LYS685 | |
| A | LYS685 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by FER and PTK6 => ECO:0000269|PubMed:12763138, ECO:0000269|PubMed:16568091, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22306293, ECO:0000269|PubMed:26293184, ECO:0000269|PubMed:31899195, ECO:0000269|PubMed:32929201, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | TYR705 | |
| A | TYR705 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:28065600 |
| Chain | Residue | Details |
| B | LYS707 | |
| A | LYS707 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR714 | |
| A | THR714 |
