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PDB: 93 results

8ET7
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Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE, OCT1
Authors:Suo, Y, Wright, N.J, Lee, S.-Y.
Deposit date:2022-10-16
Release date:2023-05-31
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET8
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Cryo-EM structure of the organic cation transporter 1 in complex with verapamil
Descriptor: (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
Authors:Suo, Y, Wright, N.J, Lee, S.-Y.
Deposit date:2022-10-16
Release date:2023-05-31
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET9
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Cryo-EM structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium
Descriptor: 1-methyl-4-phenylpyridin-1-ium, OCT2
Authors:Suo, Y, Wright, N.J, Lee, S.-Y.
Deposit date:2022-10-16
Release date:2023-05-31
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8ET6
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BU of 8et6 by Molmil
Cryo-EM structure of the organic cation transporter 1 in the apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OCT1
Authors:Suo, Y, Wright, N.J, Lee, S.-Y.
Deposit date:2022-10-16
Release date:2023-05-31
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.
Nat.Struct.Mol.Biol., 30, 2023
8FCB
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BU of 8fcb by Molmil
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ...
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8TZL
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BU of 8tzl by Molmil
Cryo-EM structure of Vibrio cholerae FtsE/FtsX/EnvC complex, full-length
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ...
Authors:Hao, A, Lee, S.-Y.
Deposit date:2023-08-27
Release date:2023-12-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae.
Structure, 32, 2024
8TZK
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BU of 8tzk by Molmil
Cryo-EM structure of Vibrio cholerae FtsE/FtsX/EnvC complex, shortened
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ...
Authors:Hao, A, Lee, S.-Y.
Deposit date:2023-08-27
Release date:2023-12-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae.
Structure, 32, 2024
8TZJ
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BU of 8tzj by Molmil
Cryo-EM structure of Vibrio cholerae FtsE/FtsX complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ...
Authors:Hao, A, Lee, S.-Y.
Deposit date:2023-08-27
Release date:2023-12-20
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae.
Structure, 32, 2024
8TZ5
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BU of 8tz5 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with N-hydroxycytidine
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxycytidine, SODIUM ION, ...
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ3
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BU of 8tz3 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, consensus reconstruction
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ2
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BU of 8tz2 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in MSP2N2 nanodiscs, apo state
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZA
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BU of 8tza by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 2, INT2-INT1-INT1 conformation
Descriptor: N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ7
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BU of 8tz7 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT1 conformation
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ4
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BU of 8tz4 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction
Descriptor: (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZD
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BU of 8tzd by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-OFS conformation (3DVA analysis)
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ6
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BU of 8tz6 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with PSI-6206
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2'-deoxy-2'-fluoro-2'-methyluridine, SODIUM ION, ...
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ8
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BU of 8tz8 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT3 conformation
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ9
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BU of 8tz9 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 2, INT2-INT2-INT2 conformation
Descriptor: N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
8TZ1
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BU of 8tz1 by Molmil
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Ribavirin
Descriptor: 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, ...
Authors:Wright, N.J, Lee, S.-Y.
Deposit date:2023-08-26
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Antiviral drug recognition and elevator-type transport motions of CNT3.
Nat.Chem.Biol., 2024
7TX6
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BU of 7tx6 by Molmil
Cryo-EM structure of the human reduced folate carrier in complex with methotrexate
Descriptor: Digitonin, METHOTREXATE, Reduced folate transporter,Soluble cytochrome b562
Authors:Wright, N.J, Fedor, J.G, Lee, S.-Y.
Deposit date:2022-02-07
Release date:2022-09-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
7TX7
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BU of 7tx7 by Molmil
Cryo-EM structure of the human reduced folate carrier
Descriptor: Digitonin, Reduced folate transporter,Soluble cytochrome b562
Authors:Wright, N.J, Fedor, J.G, Lee, S.-Y.
Deposit date:2022-02-07
Release date:2022-09-21
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Methotrexate recognition by the human reduced folate carrier SLC19A1.
Nature, 609, 2022
8FC7
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Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Descriptor: 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FC9
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Cryo-EM structure of the human TRPV4 - RhoA, apo condition
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ...
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FC8
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Cryo-EM structure of the human TRPV4 in complex with GSK1016790A
Descriptor: CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FCA
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Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
Descriptor: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4
Authors:Kwon, D.H, Lee, S.-Y, Zhang, F.
Deposit date:2022-12-01
Release date:2023-07-12
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023

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PDB entries from 2024-07-31

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