8ET8

Cryo-EM structure of the organic cation transporter 1 in complex with verapamil

Summary for 8ET8

Entry DOI	10.2210/pdb8et8/pdb
EMDB information	28588
Descriptor	OCT1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile (3 entities in total)
Functional Keywords	cation, transport, membrane protein, transport protein
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	62178.56
Authors	Suo, Y.,Wright, N.J.,Lee, S.-Y. (deposition date: 2022-10-16, release date: 2023-05-31, Last modification date: 2023-08-02)
Primary citation	Suo, Y.,Wright, N.J.,Guterres, H.,Fedor, J.G.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2. Nat.Struct.Mol.Biol., 30:1001-1011, 2023 Cited by PubMed: 37291422 DOI: 10.1038/s41594-023-01017-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.45 Å)

Structure validation