8FC8

Cryo-EM structure of the human TRPV4 in complex with GSK1016790A

Summary for 8FC8

Entry DOI	10.2210/pdb8fc8/pdb
EMDB information	28976 29331 29332
Descriptor	Transient receptor potential cation channel subfamily V member 4, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, CHOLESTEROL HEMISUCCINATE (3 entities in total)
Functional Keywords	trpv4, rhoa, gsk1016790a, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	412800.54
Authors	Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12, Last modification date: 2024-06-19)
Primary citation	Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14:3732-3732, 2023 Cited by PubMed: 37353484 DOI: 10.1038/s41467-023-39345-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.47 Å)

Structure validation