8FC8

Cryo-EM structure of the human TRPV4 in complex with GSK1016790A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Transient receptor potential cation channel subfamily V member 4	polymer	901	102057.8	4	UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) In PDB	Homo sapiens (human)	TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC
2	A, B, C, D	N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide	non-polymer		655.6	4	Chemie (XQ3)
3	B, C, D	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	4	Chemie (Y01)

Sequence modifications

A, B, C, D: 1 - 871 (UniProt: Q9HBA0)

PDB	External Database	Details
Glu 872	-	expression tag
Asn 873	-	expression tag
Ser 874	-	expression tag
Leu 875	-	expression tag
Glu 876	-	expression tag
Val 877	-	expression tag
Leu 878	-	expression tag
Phe 879	-	expression tag
Gln 880	-	expression tag
Gly 881	-	expression tag
Pro 882	-	expression tag
Asp 883	-	expression tag
Tyr 884	-	expression tag
Lys 885	-	expression tag
Asp 886	-	expression tag
Asp 887	-	expression tag
Asp 888	-	expression tag
Asp 889	-	expression tag
Lys 890	-	expression tag
Ala 891	-	expression tag
His 892	-	expression tag
His 893	-	expression tag
His 894	-	expression tag
His 895	-	expression tag
His 896	-	expression tag
His 897	-	expression tag
His 898	-	expression tag
His 899	-	expression tag
His 900	-	expression tag
His 901	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	408231.2
Non-Polymers*	Number of molecules	8
	Total formula weight	4569.4
All*	Total formula weight	412800.5

*Water molecules are not included.