8TZ4

Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction

Summary for 8TZ4

Entry DOI	10.2210/pdb8tz4/pdb
EMDB information	41733
Descriptor	Sodium/nucleoside cotransporter, (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile (2 entities in total)
Functional Keywords	membrane protein, transporter, nucleoside, transport protein
Biological source	Bos taurus (cattle)
Total number of polymer chains	3
Total formula weight	238421.58
Authors	Wright, N.J.,Lee, S.-Y. (deposition date: 2023-08-26, release date: 2024-03-13)
Primary citation	Wright, N.J.,Zhang, F.,Suo, Y.,Kong, L.,Yin, Y.,Fedor, J.G.,Sharma, K.,Borgnia, M.J.,Im, W.,Lee, S.Y. Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024 Cited by PubMed: 38418906 DOI: 10.1038/s41589-024-01559-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.23 Å)

Structure validation