8ET7

Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine

Summary for 8ET7

• Entry DOI: 10.2210/pdb8et7/pdb
• EMDB information: 28587
• Descriptor: OCT1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE (3 entities in total)
• Functional Keywords: organic cation, transport, membrane protein, transport protein
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 61979.32

Authors

Suo, Y.,Wright, N.J.,Lee, S.-Y. (deposition date: 2022-10-16, release date: 2023-05-31, Last modification date: 2023-08-02)

• Primary citation: Suo, Y.,Wright, N.J.,Guterres, H.,Fedor, J.G.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y.; Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2.; Nat.Struct.Mol.Biol., 30:1001-1011, 2023; PubMed: 37291422; DOI: 10.1038/s41594-023-01017-4

Experimental method

ELECTRON MICROSCOPY (3.77 Å)