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8ET7

Cryo-EM structure of the organic cation transporter 1 in complex with diphenhydramine

Functional Information from GO Data
ChainGOidnamespacecontents
A0005277molecular_functionacetylcholine transmembrane transporter activity
A0005326molecular_functionneurotransmitter transmembrane transporter activity
A0005330molecular_functiondopamine:sodium symporter activity
A0005334molecular_functionnorepinephrine:sodium symporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0006836biological_processneurotransmitter transport
A0006837biological_processserotonin transport
A0008504molecular_functionmonoamine transmembrane transporter activity
A0008513molecular_functionsecondary active organic cation transmembrane transporter activity
A0008514molecular_functionorganic anion transmembrane transporter activity
A0009925cellular_componentbasal plasma membrane
A0010248biological_processestablishment or maintenance of transmembrane electrochemical gradient
A0015101molecular_functionorganic cation transmembrane transporter activity
A0015132molecular_functionprostaglandin transmembrane transporter activity
A0015214molecular_functionpyrimidine nucleoside transmembrane transporter activity
A0015234molecular_functionthiamine transmembrane transporter activity
A0015489molecular_functionputrescine transmembrane transporter activity
A0015606molecular_functionspermidine transmembrane transporter activity
A0015651molecular_functionquaternary ammonium group transmembrane transporter activity
A0015695biological_processorganic cation transport
A0015697biological_processquaternary ammonium group transport
A0015732biological_processprostaglandin transport
A0015844biological_processmonoamine transport
A0015847biological_processputrescine transport
A0015848biological_processspermidine transport
A0015870biological_processacetylcholine transport
A0015872biological_processdopamine transport
A0015874biological_processnorepinephrine transport
A0015888biological_processthiamine transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0019534molecular_functiontoxin transmembrane transporter activity
A0022857molecular_functiontransmembrane transporter activity
A0042802molecular_functionidentical protein binding
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0048241biological_processepinephrine transport
A0051610biological_processserotonin uptake
A0051620biological_processnorepinephrine uptake
A0055085biological_processtransmembrane transport
A0071934biological_processthiamine transmembrane transport
A0072237biological_processmetanephric proximal tubule development
A0072530biological_processpurine-containing compound transmembrane transport
A0090494biological_processdopamine uptake
A0098655biological_processmonoatomic cation transmembrane transport
A0098793cellular_componentpresynapse
A0150104biological_processtransport across blood-brain barrier
A1901235molecular_function(R)-carnitine transmembrane transporter activity
A1902270biological_process(R)-carnitine transmembrane transport
A1902616biological_processacyl carnitine transmembrane transport
A1903711biological_processspermidine transmembrane transport
A1990748biological_processcellular detoxification
A1990962biological_processxenobiotic transport across blood-brain barrier
Functional Information from PROSITE/UniProt
site_idPS00216
Number of Residues18
DetailsSUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VGYIADRFGRKlcllatT
ChainResidueDetails
AVAL166-THR183

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues148
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ALA21
AASP171-LYS176
ASER230-THR235
AGLU284-THR347
AASP398-ARG402
AASN453-LEU464
APRO514-THR554

site_idSWS_FT_FI2
Number of Residues242
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
APHE22-LEU42
AILE432-VAL452
AGLY465-PHE485
AGLY493-LEU513
ALEU150-ALA170
ALEU177-PRO197
ALEU207-GLY229
AVAL236-TYR256
ATRP263-PRO283
APHE348-MET368
ALEU377-ILE397
AILE403-ILE423

site_idSWS_FT_FI3
Number of Residues139
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLY43-ASP149
AASP198-ARG206
AALA257-ARG262
AGLY369-TYR376
ASER424-ASN431
AARG486-GLN492

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O08966
ChainResidueDetails
ASER333

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR541

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN71

219869

PDB entries from 2024-05-15

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