8FC7
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Summary for 8FC7
Entry DOI | 10.2210/pdb8fc7/pdb |
EMDB information | 28975 29030 29031 |
Descriptor | Transient receptor potential cation channel subfamily V member 4, Transforming protein RhoA, 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, ... (5 entities in total) |
Functional Keywords | trpv4, rhoa, gsk2798745, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 499139.96 |
Authors | Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12, Last modification date: 2024-06-19) |
Primary citation | Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14:3732-3732, 2023 Cited by PubMed: 37353484DOI: 10.1038/s41467-023-39345-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
Download full validation report