8FC7

Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745

Summary for 8FC7

• Entry DOI: 10.2210/pdb8fc7/pdb
• EMDB information: 28975 29030 29031
• Descriptor: Transient receptor potential cation channel subfamily V member 4, Transforming protein RhoA, 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, ... (5 entities in total)
• Functional Keywords: trpv4, rhoa, gsk2798745, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 499139.96

Authors

Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12)

• Primary citation: Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y.; TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.; Nat Commun, 14:3732-3732, 2023; PubMed: 37353484; DOI: 10.1038/s41467-023-39345-0

Experimental method

ELECTRON MICROSCOPY (3.3 Å)