8FC7

Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001666	biological_process	response to hypoxia
A	0002024	biological_process	diet induced thermogenesis
A	0003779	molecular_function	actin binding
A	0005034	molecular_function	osmosensor activity
A	0005080	molecular_function	protein kinase C binding
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005912	cellular_component	adherens junction
A	0005925	cellular_component	focal adhesion
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0006884	biological_process	cell volume homeostasis
A	0006970	biological_process	response to osmotic stress
A	0006971	biological_process	hypotonic response
A	0007015	biological_process	actin filament organization
A	0007043	biological_process	cell-cell junction assembly
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007231	biological_process	osmosensory signaling pathway
A	0008017	molecular_function	microtubule binding
A	0008289	molecular_function	lipid binding
A	0009612	biological_process	response to mechanical stimulus
A	0009986	cellular_component	cell surface
A	0010628	biological_process	positive regulation of gene expression
A	0010759	biological_process	positive regulation of macrophage chemotaxis
A	0010977	biological_process	negative regulation of neuron projection development
A	0015275	molecular_function	stretch-activated, monoatomic cation-selective, calcium channel activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0019901	molecular_function	protein kinase binding
A	0030027	cellular_component	lamellipodium
A	0030036	biological_process	actin cytoskeleton organization
A	0030103	biological_process	vasopressin secretion
A	0030175	cellular_component	filopodium
A	0030426	cellular_component	growth cone
A	0030864	cellular_component	cortical actin cytoskeleton
A	0031117	biological_process	positive regulation of microtubule depolymerization
A	0032587	cellular_component	ruffle membrane
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032868	biological_process	response to insulin
A	0034605	biological_process	cellular response to heat
A	0042169	molecular_function	SH2 domain binding
A	0042538	biological_process	hyperosmotic salinity response
A	0042593	biological_process	glucose homeostasis
A	0042802	molecular_function	identical protein binding
A	0043014	molecular_function	alpha-tubulin binding
A	0043117	biological_process	positive regulation of vascular permeability
A	0043622	biological_process	cortical microtubule organization
A	0045989	biological_process	positive regulation of striated muscle contraction
A	0046330	biological_process	positive regulation of JNK cascade
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0047484	biological_process	regulation of response to osmotic stress
A	0048487	molecular_function	beta-tubulin binding
A	0050729	biological_process	positive regulation of inflammatory response
A	0050891	biological_process	multicellular organismal-level water homeostasis
A	0051015	molecular_function	actin filament binding
A	0055085	biological_process	transmembrane transport
A	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
A	0070161	cellular_component	anchoring junction
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0070509	biological_process	calcium ion import
A	0070588	biological_process	calcium ion transmembrane transport
A	0071470	biological_process	cellular response to osmotic stress
A	0071476	biological_process	cellular hypotonic response
A	0071477	biological_process	cellular hypotonic salinity response
A	0071639	biological_process	positive regulation of monocyte chemotactic protein-1 production
A	0071642	biological_process	positive regulation of macrophage inflammatory protein 1 alpha production
A	0071651	biological_process	positive regulation of chemokine (C-C motif) ligand 5 production
A	0097009	biological_process	energy homeostasis
A	0097497	biological_process	blood vessel endothelial cell delamination
A	1902656	biological_process	calcium ion import into cytosol
A	1903444	biological_process	negative regulation of brown fat cell differentiation
A	1903715	biological_process	regulation of aerobic respiration
A	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001666	biological_process	response to hypoxia
B	0002024	biological_process	diet induced thermogenesis
B	0003779	molecular_function	actin binding
B	0005034	molecular_function	osmosensor activity
B	0005080	molecular_function	protein kinase C binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005524	molecular_function	ATP binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005881	cellular_component	cytoplasmic microtubule
B	0005886	cellular_component	plasma membrane
B	0005912	cellular_component	adherens junction
B	0005925	cellular_component	focal adhesion
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0006884	biological_process	cell volume homeostasis
B	0006970	biological_process	response to osmotic stress
B	0006971	biological_process	hypotonic response
B	0007015	biological_process	actin filament organization
B	0007043	biological_process	cell-cell junction assembly
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0007231	biological_process	osmosensory signaling pathway
B	0008017	molecular_function	microtubule binding
B	0008289	molecular_function	lipid binding
B	0009612	biological_process	response to mechanical stimulus
B	0009986	cellular_component	cell surface
B	0010628	biological_process	positive regulation of gene expression
B	0010759	biological_process	positive regulation of macrophage chemotaxis
B	0010977	biological_process	negative regulation of neuron projection development
B	0015275	molecular_function	stretch-activated, monoatomic cation-selective, calcium channel activity
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0019901	molecular_function	protein kinase binding
B	0030027	cellular_component	lamellipodium
B	0030036	biological_process	actin cytoskeleton organization
B	0030103	biological_process	vasopressin secretion
B	0030175	cellular_component	filopodium
B	0030426	cellular_component	growth cone
B	0030864	cellular_component	cortical actin cytoskeleton
B	0031117	biological_process	positive regulation of microtubule depolymerization
B	0032587	cellular_component	ruffle membrane
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0032868	biological_process	response to insulin
B	0034605	biological_process	cellular response to heat
B	0042169	molecular_function	SH2 domain binding
B	0042538	biological_process	hyperosmotic salinity response
B	0042593	biological_process	glucose homeostasis
B	0042802	molecular_function	identical protein binding
B	0043014	molecular_function	alpha-tubulin binding
B	0043117	biological_process	positive regulation of vascular permeability
B	0043622	biological_process	cortical microtubule organization
B	0045989	biological_process	positive regulation of striated muscle contraction
B	0046330	biological_process	positive regulation of JNK cascade
B	0046785	biological_process	microtubule polymerization
B	0046872	molecular_function	metal ion binding
B	0047484	biological_process	regulation of response to osmotic stress
B	0048487	molecular_function	beta-tubulin binding
B	0050729	biological_process	positive regulation of inflammatory response
B	0050891	biological_process	multicellular organismal-level water homeostasis
B	0051015	molecular_function	actin filament binding
B	0055085	biological_process	transmembrane transport
B	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
B	0070161	cellular_component	anchoring junction
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0070509	biological_process	calcium ion import
B	0070588	biological_process	calcium ion transmembrane transport
B	0071470	biological_process	cellular response to osmotic stress
B	0071476	biological_process	cellular hypotonic response
B	0071477	biological_process	cellular hypotonic salinity response
B	0071639	biological_process	positive regulation of monocyte chemotactic protein-1 production
B	0071642	biological_process	positive regulation of macrophage inflammatory protein 1 alpha production
B	0071651	biological_process	positive regulation of chemokine (C-C motif) ligand 5 production
B	0097009	biological_process	energy homeostasis
B	0097497	biological_process	blood vessel endothelial cell delamination
B	1902656	biological_process	calcium ion import into cytosol
B	1903444	biological_process	negative regulation of brown fat cell differentiation
B	1903715	biological_process	regulation of aerobic respiration
B	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001666	biological_process	response to hypoxia
C	0002024	biological_process	diet induced thermogenesis
C	0003779	molecular_function	actin binding
C	0005034	molecular_function	osmosensor activity
C	0005080	molecular_function	protein kinase C binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005881	cellular_component	cytoplasmic microtubule
C	0005886	cellular_component	plasma membrane
C	0005912	cellular_component	adherens junction
C	0005925	cellular_component	focal adhesion
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0006884	biological_process	cell volume homeostasis
C	0006970	biological_process	response to osmotic stress
C	0006971	biological_process	hypotonic response
C	0007015	biological_process	actin filament organization
C	0007043	biological_process	cell-cell junction assembly
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007231	biological_process	osmosensory signaling pathway
C	0008017	molecular_function	microtubule binding
C	0008289	molecular_function	lipid binding
C	0009612	biological_process	response to mechanical stimulus
C	0009986	cellular_component	cell surface
C	0010628	biological_process	positive regulation of gene expression
C	0010759	biological_process	positive regulation of macrophage chemotaxis
C	0010977	biological_process	negative regulation of neuron projection development
C	0015275	molecular_function	stretch-activated, monoatomic cation-selective, calcium channel activity
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0019901	molecular_function	protein kinase binding
C	0030027	cellular_component	lamellipodium
C	0030036	biological_process	actin cytoskeleton organization
C	0030103	biological_process	vasopressin secretion
C	0030175	cellular_component	filopodium
C	0030426	cellular_component	growth cone
C	0030864	cellular_component	cortical actin cytoskeleton
C	0031117	biological_process	positive regulation of microtubule depolymerization
C	0032587	cellular_component	ruffle membrane
C	0032755	biological_process	positive regulation of interleukin-6 production
C	0032868	biological_process	response to insulin
C	0034605	biological_process	cellular response to heat
C	0042169	molecular_function	SH2 domain binding
C	0042538	biological_process	hyperosmotic salinity response
C	0042593	biological_process	glucose homeostasis
C	0042802	molecular_function	identical protein binding
C	0043014	molecular_function	alpha-tubulin binding
C	0043117	biological_process	positive regulation of vascular permeability
C	0043622	biological_process	cortical microtubule organization
C	0045989	biological_process	positive regulation of striated muscle contraction
C	0046330	biological_process	positive regulation of JNK cascade
C	0046785	biological_process	microtubule polymerization
C	0046872	molecular_function	metal ion binding
C	0047484	biological_process	regulation of response to osmotic stress
C	0048487	molecular_function	beta-tubulin binding
C	0050729	biological_process	positive regulation of inflammatory response
C	0050891	biological_process	multicellular organismal-level water homeostasis
C	0051015	molecular_function	actin filament binding
C	0055085	biological_process	transmembrane transport
C	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
C	0070161	cellular_component	anchoring junction
C	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
C	0070509	biological_process	calcium ion import
C	0070588	biological_process	calcium ion transmembrane transport
C	0071470	biological_process	cellular response to osmotic stress
C	0071476	biological_process	cellular hypotonic response
C	0071477	biological_process	cellular hypotonic salinity response
C	0071639	biological_process	positive regulation of monocyte chemotactic protein-1 production
C	0071642	biological_process	positive regulation of macrophage inflammatory protein 1 alpha production
C	0071651	biological_process	positive regulation of chemokine (C-C motif) ligand 5 production
C	0097009	biological_process	energy homeostasis
C	0097497	biological_process	blood vessel endothelial cell delamination
C	1902656	biological_process	calcium ion import into cytosol
C	1903444	biological_process	negative regulation of brown fat cell differentiation
C	1903715	biological_process	regulation of aerobic respiration
C	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0001666	biological_process	response to hypoxia
D	0002024	biological_process	diet induced thermogenesis
D	0003779	molecular_function	actin binding
D	0005034	molecular_function	osmosensor activity
D	0005080	molecular_function	protein kinase C binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005524	molecular_function	ATP binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005881	cellular_component	cytoplasmic microtubule
D	0005886	cellular_component	plasma membrane
D	0005912	cellular_component	adherens junction
D	0005925	cellular_component	focal adhesion
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0006884	biological_process	cell volume homeostasis
D	0006970	biological_process	response to osmotic stress
D	0006971	biological_process	hypotonic response
D	0007015	biological_process	actin filament organization
D	0007043	biological_process	cell-cell junction assembly
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007231	biological_process	osmosensory signaling pathway
D	0008017	molecular_function	microtubule binding
D	0008289	molecular_function	lipid binding
D	0009612	biological_process	response to mechanical stimulus
D	0009986	cellular_component	cell surface
D	0010628	biological_process	positive regulation of gene expression
D	0010759	biological_process	positive regulation of macrophage chemotaxis
D	0010977	biological_process	negative regulation of neuron projection development
D	0015275	molecular_function	stretch-activated, monoatomic cation-selective, calcium channel activity
D	0016020	cellular_component	membrane
D	0016324	cellular_component	apical plasma membrane
D	0019901	molecular_function	protein kinase binding
D	0030027	cellular_component	lamellipodium
D	0030036	biological_process	actin cytoskeleton organization
D	0030103	biological_process	vasopressin secretion
D	0030175	cellular_component	filopodium
D	0030426	cellular_component	growth cone
D	0030864	cellular_component	cortical actin cytoskeleton
D	0031117	biological_process	positive regulation of microtubule depolymerization
D	0032587	cellular_component	ruffle membrane
D	0032755	biological_process	positive regulation of interleukin-6 production
D	0032868	biological_process	response to insulin
D	0034605	biological_process	cellular response to heat
D	0042169	molecular_function	SH2 domain binding
D	0042538	biological_process	hyperosmotic salinity response
D	0042593	biological_process	glucose homeostasis
D	0042802	molecular_function	identical protein binding
D	0043014	molecular_function	alpha-tubulin binding
D	0043117	biological_process	positive regulation of vascular permeability
D	0043622	biological_process	cortical microtubule organization
D	0045989	biological_process	positive regulation of striated muscle contraction
D	0046330	biological_process	positive regulation of JNK cascade
D	0046785	biological_process	microtubule polymerization
D	0046872	molecular_function	metal ion binding
D	0047484	biological_process	regulation of response to osmotic stress
D	0048487	molecular_function	beta-tubulin binding
D	0050729	biological_process	positive regulation of inflammatory response
D	0050891	biological_process	multicellular organismal-level water homeostasis
D	0051015	molecular_function	actin filament binding
D	0055085	biological_process	transmembrane transport
D	0060351	biological_process	cartilage development involved in endochondral bone morphogenesis
D	0070161	cellular_component	anchoring junction
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0070509	biological_process	calcium ion import
D	0070588	biological_process	calcium ion transmembrane transport
D	0071470	biological_process	cellular response to osmotic stress
D	0071476	biological_process	cellular hypotonic response
D	0071477	biological_process	cellular hypotonic salinity response
D	0071639	biological_process	positive regulation of monocyte chemotactic protein-1 production
D	0071642	biological_process	positive regulation of macrophage inflammatory protein 1 alpha production
D	0071651	biological_process	positive regulation of chemokine (C-C motif) ligand 5 production
D	0097009	biological_process	energy homeostasis
D	0097497	biological_process	blood vessel endothelial cell delamination
D	1902656	biological_process	calcium ion import into cytosol
D	1903444	biological_process	negative regulation of brown fat cell differentiation
D	1903715	biological_process	regulation of aerobic respiration
D	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
E	0000902	biological_process	cell morphogenesis
E	0001764	biological_process	neuron migration
E	0001822	biological_process	kidney development
E	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
E	0002363	biological_process	alpha-beta T cell lineage commitment
E	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
E	0003189	biological_process	aortic valve formation
E	0003924	molecular_function	GTPase activity
E	0003925	molecular_function	G protein activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005768	cellular_component	endosome
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0005938	cellular_component	cell cortex
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0007010	biological_process	cytoskeleton organization
E	0007155	biological_process	cell adhesion
E	0007160	biological_process	cell-matrix adhesion
E	0007264	biological_process	small GTPase-mediated signal transduction
E	0007266	biological_process	Rho protein signal transduction
E	0007519	biological_process	skeletal muscle tissue development
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0010812	biological_process	negative regulation of cell-substrate adhesion
E	0010975	biological_process	regulation of neuron projection development
E	0016477	biological_process	cell migration
E	0016787	molecular_function	hydrolase activity
E	0017022	molecular_function	myosin binding
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0021795	biological_process	cerebral cortex cell migration
E	0021861	biological_process	forebrain radial glial cell differentiation
E	0030027	cellular_component	lamellipodium
E	0030036	biological_process	actin cytoskeleton organization
E	0030054	cellular_component	cell junction
E	0030154	biological_process	cell differentiation
E	0030334	biological_process	regulation of cell migration
E	0030425	cellular_component	dendrite
E	0030496	cellular_component	midbody
E	0030521	biological_process	androgen receptor signaling pathway
E	0030667	cellular_component	secretory granule membrane
E	0031122	biological_process	cytoplasmic microtubule organization
E	0031982	cellular_component	vesicle
E	0032154	cellular_component	cleavage furrow
E	0032467	biological_process	positive regulation of cytokinesis
E	0032587	cellular_component	ruffle membrane
E	0032956	biological_process	regulation of actin cytoskeleton organization
E	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
E	0033688	biological_process	regulation of osteoblast proliferation
E	0034329	biological_process	cell junction assembly
E	0034446	biological_process	substrate adhesion-dependent cell spreading
E	0035385	biological_process	Roundabout signaling pathway
E	0036089	biological_process	cleavage furrow formation
E	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
E	0042476	biological_process	odontogenesis
E	0042995	cellular_component	cell projection
E	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
E	0043149	biological_process	stress fiber assembly
E	0043197	cellular_component	dendritic spine
E	0043296	cellular_component	apical junction complex
E	0043297	biological_process	apical junction assembly
E	0043366	biological_process	beta selection
E	0043542	biological_process	endothelial cell migration
E	0043931	biological_process	ossification involved in bone maturation
E	0044319	biological_process	wound healing, spreading of cells
E	0045198	biological_process	establishment of epithelial cell apical/basal polarity
E	0045666	biological_process	positive regulation of neuron differentiation
E	0045792	biological_process	negative regulation of cell size
E	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
E	0050919	biological_process	negative chemotaxis
E	0051301	biological_process	cell division
E	0051496	biological_process	positive regulation of stress fiber assembly
E	0051893	biological_process	regulation of focal adhesion assembly
E	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
E	0060193	biological_process	positive regulation of lipase activity
E	0061430	biological_process	bone trabecula morphogenesis
E	0070062	cellular_component	extracellular exosome
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0071345	biological_process	cellular response to cytokine stimulus
E	0071526	biological_process	semaphorin-plexin signaling pathway
E	0071803	biological_process	positive regulation of podosome assembly
E	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
E	0071944	cellular_component	cell periphery
E	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
E	0090307	biological_process	mitotic spindle assembly
E	0090324	biological_process	negative regulation of oxidative phosphorylation
E	0097049	biological_process	motor neuron apoptotic process
E	0097498	biological_process	endothelial tube lumen extension
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099159	biological_process	regulation of modification of postsynaptic structure
E	0101003	cellular_component	ficolin-1-rich granule membrane
E	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
E	1902766	biological_process	skeletal muscle satellite cell migration
E	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
E	1903673	biological_process	mitotic cleavage furrow formation
E	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
E	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
E	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
E	1990869	biological_process	cellular response to chemokine
E	2000177	biological_process	regulation of neural precursor cell proliferation
E	2000406	biological_process	positive regulation of T cell migration
E	2000672	biological_process	negative regulation of motor neuron apoptotic process
F	0000902	biological_process	cell morphogenesis
F	0001764	biological_process	neuron migration
F	0001822	biological_process	kidney development
F	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
F	0002363	biological_process	alpha-beta T cell lineage commitment
F	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
F	0003189	biological_process	aortic valve formation
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005768	cellular_component	endosome
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0005938	cellular_component	cell cortex
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0007010	biological_process	cytoskeleton organization
F	0007155	biological_process	cell adhesion
F	0007160	biological_process	cell-matrix adhesion
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0007266	biological_process	Rho protein signal transduction
F	0007519	biological_process	skeletal muscle tissue development
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0010812	biological_process	negative regulation of cell-substrate adhesion
F	0010975	biological_process	regulation of neuron projection development
F	0016477	biological_process	cell migration
F	0016787	molecular_function	hydrolase activity
F	0017022	molecular_function	myosin binding
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0021795	biological_process	cerebral cortex cell migration
F	0021861	biological_process	forebrain radial glial cell differentiation
F	0030027	cellular_component	lamellipodium
F	0030036	biological_process	actin cytoskeleton organization
F	0030054	cellular_component	cell junction
F	0030154	biological_process	cell differentiation
F	0030334	biological_process	regulation of cell migration
F	0030425	cellular_component	dendrite
F	0030496	cellular_component	midbody
F	0030521	biological_process	androgen receptor signaling pathway
F	0030667	cellular_component	secretory granule membrane
F	0031122	biological_process	cytoplasmic microtubule organization
F	0031982	cellular_component	vesicle
F	0032154	cellular_component	cleavage furrow
F	0032467	biological_process	positive regulation of cytokinesis
F	0032587	cellular_component	ruffle membrane
F	0032956	biological_process	regulation of actin cytoskeleton organization
F	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
F	0033688	biological_process	regulation of osteoblast proliferation
F	0034329	biological_process	cell junction assembly
F	0034446	biological_process	substrate adhesion-dependent cell spreading
F	0035385	biological_process	Roundabout signaling pathway
F	0036089	biological_process	cleavage furrow formation
F	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
F	0042476	biological_process	odontogenesis
F	0042995	cellular_component	cell projection
F	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
F	0043149	biological_process	stress fiber assembly
F	0043197	cellular_component	dendritic spine
F	0043296	cellular_component	apical junction complex
F	0043297	biological_process	apical junction assembly
F	0043366	biological_process	beta selection
F	0043542	biological_process	endothelial cell migration
F	0043931	biological_process	ossification involved in bone maturation
F	0044319	biological_process	wound healing, spreading of cells
F	0045198	biological_process	establishment of epithelial cell apical/basal polarity
F	0045666	biological_process	positive regulation of neuron differentiation
F	0045792	biological_process	negative regulation of cell size
F	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
F	0050919	biological_process	negative chemotaxis
F	0051301	biological_process	cell division
F	0051496	biological_process	positive regulation of stress fiber assembly
F	0051893	biological_process	regulation of focal adhesion assembly
F	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
F	0060193	biological_process	positive regulation of lipase activity
F	0061430	biological_process	bone trabecula morphogenesis
F	0070062	cellular_component	extracellular exosome
F	0070507	biological_process	regulation of microtubule cytoskeleton organization
F	0071222	biological_process	cellular response to lipopolysaccharide
F	0071345	biological_process	cellular response to cytokine stimulus
F	0071526	biological_process	semaphorin-plexin signaling pathway
F	0071803	biological_process	positive regulation of podosome assembly
F	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
F	0071944	cellular_component	cell periphery
F	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
F	0090307	biological_process	mitotic spindle assembly
F	0090324	biological_process	negative regulation of oxidative phosphorylation
F	0097049	biological_process	motor neuron apoptotic process
F	0097498	biological_process	endothelial tube lumen extension
F	0098794	cellular_component	postsynapse
F	0098978	cellular_component	glutamatergic synapse
F	0099159	biological_process	regulation of modification of postsynaptic structure
F	0101003	cellular_component	ficolin-1-rich granule membrane
F	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
F	1902766	biological_process	skeletal muscle satellite cell migration
F	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
F	1903673	biological_process	mitotic cleavage furrow formation
F	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
F	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
F	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
F	1990869	biological_process	cellular response to chemokine
F	2000177	biological_process	regulation of neural precursor cell proliferation
F	2000406	biological_process	positive regulation of T cell migration
F	2000672	biological_process	negative regulation of motor neuron apoptotic process
G	0000902	biological_process	cell morphogenesis
G	0001764	biological_process	neuron migration
G	0001822	biological_process	kidney development
G	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
G	0002363	biological_process	alpha-beta T cell lineage commitment
G	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
G	0003189	biological_process	aortic valve formation
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005768	cellular_component	endosome
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0005938	cellular_component	cell cortex
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0007010	biological_process	cytoskeleton organization
G	0007155	biological_process	cell adhesion
G	0007160	biological_process	cell-matrix adhesion
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0007266	biological_process	Rho protein signal transduction
G	0007519	biological_process	skeletal muscle tissue development
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0010812	biological_process	negative regulation of cell-substrate adhesion
G	0010975	biological_process	regulation of neuron projection development
G	0016477	biological_process	cell migration
G	0016787	molecular_function	hydrolase activity
G	0017022	molecular_function	myosin binding
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0021795	biological_process	cerebral cortex cell migration
G	0021861	biological_process	forebrain radial glial cell differentiation
G	0030027	cellular_component	lamellipodium
G	0030036	biological_process	actin cytoskeleton organization
G	0030054	cellular_component	cell junction
G	0030154	biological_process	cell differentiation
G	0030334	biological_process	regulation of cell migration
G	0030425	cellular_component	dendrite
G	0030496	cellular_component	midbody
G	0030521	biological_process	androgen receptor signaling pathway
G	0030667	cellular_component	secretory granule membrane
G	0031122	biological_process	cytoplasmic microtubule organization
G	0031982	cellular_component	vesicle
G	0032154	cellular_component	cleavage furrow
G	0032467	biological_process	positive regulation of cytokinesis
G	0032587	cellular_component	ruffle membrane
G	0032956	biological_process	regulation of actin cytoskeleton organization
G	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
G	0033688	biological_process	regulation of osteoblast proliferation
G	0034329	biological_process	cell junction assembly
G	0034446	biological_process	substrate adhesion-dependent cell spreading
G	0035385	biological_process	Roundabout signaling pathway
G	0036089	biological_process	cleavage furrow formation
G	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
G	0042476	biological_process	odontogenesis
G	0042995	cellular_component	cell projection
G	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
G	0043149	biological_process	stress fiber assembly
G	0043197	cellular_component	dendritic spine
G	0043296	cellular_component	apical junction complex
G	0043297	biological_process	apical junction assembly
G	0043366	biological_process	beta selection
G	0043542	biological_process	endothelial cell migration
G	0043931	biological_process	ossification involved in bone maturation
G	0044319	biological_process	wound healing, spreading of cells
G	0045198	biological_process	establishment of epithelial cell apical/basal polarity
G	0045666	biological_process	positive regulation of neuron differentiation
G	0045792	biological_process	negative regulation of cell size
G	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
G	0050919	biological_process	negative chemotaxis
G	0051301	biological_process	cell division
G	0051496	biological_process	positive regulation of stress fiber assembly
G	0051893	biological_process	regulation of focal adhesion assembly
G	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
G	0060193	biological_process	positive regulation of lipase activity
G	0061430	biological_process	bone trabecula morphogenesis
G	0070062	cellular_component	extracellular exosome
G	0070507	biological_process	regulation of microtubule cytoskeleton organization
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0071345	biological_process	cellular response to cytokine stimulus
G	0071526	biological_process	semaphorin-plexin signaling pathway
G	0071803	biological_process	positive regulation of podosome assembly
G	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
G	0071944	cellular_component	cell periphery
G	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
G	0090307	biological_process	mitotic spindle assembly
G	0090324	biological_process	negative regulation of oxidative phosphorylation
G	0097049	biological_process	motor neuron apoptotic process
G	0097498	biological_process	endothelial tube lumen extension
G	0098794	cellular_component	postsynapse
G	0098978	cellular_component	glutamatergic synapse
G	0099159	biological_process	regulation of modification of postsynaptic structure
G	0101003	cellular_component	ficolin-1-rich granule membrane
G	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
G	1902766	biological_process	skeletal muscle satellite cell migration
G	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
G	1903673	biological_process	mitotic cleavage furrow formation
G	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
G	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
G	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
G	1990869	biological_process	cellular response to chemokine
G	2000177	biological_process	regulation of neural precursor cell proliferation
G	2000406	biological_process	positive regulation of T cell migration
G	2000672	biological_process	negative regulation of motor neuron apoptotic process
H	0000902	biological_process	cell morphogenesis
H	0001764	biological_process	neuron migration
H	0001822	biological_process	kidney development
H	0001998	biological_process	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
H	0002363	biological_process	alpha-beta T cell lineage commitment
H	0003100	biological_process	regulation of systemic arterial blood pressure by endothelin
H	0003189	biological_process	aortic valve formation
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005768	cellular_component	endosome
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0005938	cellular_component	cell cortex
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0007010	biological_process	cytoskeleton organization
H	0007155	biological_process	cell adhesion
H	0007160	biological_process	cell-matrix adhesion
H	0007264	biological_process	small GTPase-mediated signal transduction
H	0007266	biological_process	Rho protein signal transduction
H	0007519	biological_process	skeletal muscle tissue development
H	0009898	cellular_component	cytoplasmic side of plasma membrane
H	0010812	biological_process	negative regulation of cell-substrate adhesion
H	0010975	biological_process	regulation of neuron projection development
H	0016477	biological_process	cell migration
H	0016787	molecular_function	hydrolase activity
H	0017022	molecular_function	myosin binding
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0021795	biological_process	cerebral cortex cell migration
H	0021861	biological_process	forebrain radial glial cell differentiation
H	0030027	cellular_component	lamellipodium
H	0030036	biological_process	actin cytoskeleton organization
H	0030054	cellular_component	cell junction
H	0030154	biological_process	cell differentiation
H	0030334	biological_process	regulation of cell migration
H	0030425	cellular_component	dendrite
H	0030496	cellular_component	midbody
H	0030521	biological_process	androgen receptor signaling pathway
H	0030667	cellular_component	secretory granule membrane
H	0031122	biological_process	cytoplasmic microtubule organization
H	0031982	cellular_component	vesicle
H	0032154	cellular_component	cleavage furrow
H	0032467	biological_process	positive regulation of cytokinesis
H	0032587	cellular_component	ruffle membrane
H	0032956	biological_process	regulation of actin cytoskeleton organization
H	0033144	biological_process	negative regulation of intracellular steroid hormone receptor signaling pathway
H	0033688	biological_process	regulation of osteoblast proliferation
H	0034329	biological_process	cell junction assembly
H	0034446	biological_process	substrate adhesion-dependent cell spreading
H	0035385	biological_process	Roundabout signaling pathway
H	0036089	biological_process	cleavage furrow formation
H	0038027	biological_process	apolipoprotein A-I-mediated signaling pathway
H	0042476	biological_process	odontogenesis
H	0042995	cellular_component	cell projection
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043149	biological_process	stress fiber assembly
H	0043197	cellular_component	dendritic spine
H	0043296	cellular_component	apical junction complex
H	0043297	biological_process	apical junction assembly
H	0043366	biological_process	beta selection
H	0043542	biological_process	endothelial cell migration
H	0043931	biological_process	ossification involved in bone maturation
H	0044319	biological_process	wound healing, spreading of cells
H	0045198	biological_process	establishment of epithelial cell apical/basal polarity
H	0045666	biological_process	positive regulation of neuron differentiation
H	0045792	biological_process	negative regulation of cell size
H	0046638	biological_process	positive regulation of alpha-beta T cell differentiation
H	0050919	biological_process	negative chemotaxis
H	0051301	biological_process	cell division
H	0051496	biological_process	positive regulation of stress fiber assembly
H	0051893	biological_process	regulation of focal adhesion assembly
H	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
H	0060193	biological_process	positive regulation of lipase activity
H	0061430	biological_process	bone trabecula morphogenesis
H	0070062	cellular_component	extracellular exosome
H	0070507	biological_process	regulation of microtubule cytoskeleton organization
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0071345	biological_process	cellular response to cytokine stimulus
H	0071526	biological_process	semaphorin-plexin signaling pathway
H	0071803	biological_process	positive regulation of podosome assembly
H	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
H	0071944	cellular_component	cell periphery
H	0090051	biological_process	negative regulation of cell migration involved in sprouting angiogenesis
H	0090307	biological_process	mitotic spindle assembly
H	0090324	biological_process	negative regulation of oxidative phosphorylation
H	0097049	biological_process	motor neuron apoptotic process
H	0097498	biological_process	endothelial tube lumen extension
H	0098794	cellular_component	postsynapse
H	0098978	cellular_component	glutamatergic synapse
H	0099159	biological_process	regulation of modification of postsynaptic structure
H	0101003	cellular_component	ficolin-1-rich granule membrane
H	1901224	biological_process	positive regulation of non-canonical NF-kappaB signal transduction
H	1902766	biological_process	skeletal muscle satellite cell migration
H	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
H	1903673	biological_process	mitotic cleavage furrow formation
H	1904695	biological_process	positive regulation of vascular associated smooth muscle contraction
H	1904996	biological_process	positive regulation of leukocyte adhesion to vascular endothelial cell
H	1905274	biological_process	regulation of modification of postsynaptic actin cytoskeleton
H	1990869	biological_process	cellular response to chemokine
H	2000177	biological_process	regulation of neural precursor cell proliferation
H	2000406	biological_process	positive regulation of T cell migration
H	2000672	biological_process	negative regulation of motor neuron apoptotic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804

Chain	Residue	Details
E	GLY12
C	LYS535-GLY547
C	ARG594-LYS608
C	GLY723-LEU871
D	MET1-VAL469
D	LYS535-GLY547
D	ARG594-LYS608
D	GLY723-LEU871
E	ASN117
F	GLY12
F	ASN117
G	GLY12
G	ASN117
H	GLY12
H	ASN117
C	MET1-VAL469

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P62820

Chain	Residue	Details
E	PHE30
H	PHE30
H	ASP59
H	SER160
C	SER470-TYR490
C	TYR508-MET534
C	SER548-LEU568
C	ALA573-THR593
C	ILE609-LEU636
C	VAL694-VAL722
D	SER470-TYR490
E	ASP59
D	TYR508-MET534
D	SER548-LEU568
D	ALA573-THR593
D	ILE609-LEU636
D	VAL694-VAL722
E	SER160
F	PHE30
F	ASP59
F	SER160
G	PHE30
G	ASP59
G	SER160

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863

Chain	Residue	Details
E	GLY189
C	ALA569-GLU572
C	ASN637-THR665
C	LEU686-VAL693
D	TYR491-ASP507
D	ALA569-GLU572
D	ASN637-THR665
D	LEU686-VAL693
F	GLY189
G	GLY189
H	GLY189
B	TYR491-ASP507
B	ALA569-GLU572
B	ASN637-THR665
B	LEU686-VAL693
C	TYR491-ASP507

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538

Chain	Residue	Details
E	TYR34
F	TYR34
G	TYR34
H	TYR34

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103

Chain	Residue	Details
E	THR37
B	ARG248
C	LYS192
C	LYS197
C	ASN201
C	TYR236
C	ARG248
D	LYS192
D	LYS197
D	ASN201
D	TYR236
F	THR37
D	ARG248
G	THR37
H	THR37
A	ARG248
B	LYS192
B	LYS197
B	ASN201
B	TYR236

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215

Chain	Residue	Details
E	ASN41
D	ARG249
D	ASN296
D	LYS344
F	ASN41
G	ASN41
H	ASN41
B	ASN296
B	LYS344
C	ARG249
C	ASN296
C	LYS344

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0

Chain	Residue	Details
E	GLN63
F	GLN63
G	GLN63
H	GLN63

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591

Chain	Residue	Details
E	SER188
D	TYR110
D	TYR253
D	TYR805
F	SER188
G	SER188
H	SER188
B	TYR253
B	TYR805
C	TYR110
C	TYR253
C	TYR805

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585

Chain	Residue	Details
E	CYS190
F	CYS190
G	CYS190
H	CYS190

---

site_id	SWS_FT_FI10
Number of Residues	12
Details	LIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757

Chain	Residue	Details
E	LYS185
H	LYS185
H	LYS186
H	LYS187
E	LYS186
E	LYS187
F	LYS185
F	LYS186
F	LYS187
G	LYS185
G	LYS186
G	LYS187

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	LIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585

Chain	Residue	Details
E	CYS190
F	CYS190
G	CYS190
H	CYS190

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704

Chain	Residue	Details
E	TYR34
F	TYR34
G	TYR34
H	TYR34

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059

Chain	Residue	Details
E	THR37
F	THR37
G	THR37
H	THR37

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831

Chain	Residue	Details
E	LYS135
F	LYS135
G	LYS135
H	LYS135

---