8FC7
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, G, H (A, B, C, D) | Transient receptor potential cation channel subfamily V member 4 | polymer | 901 | 102057.8 | 4 | UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
| 2 | B, C, D, E (E, F, G, H) | Transforming protein RhoA | polymer | 193 | 21799.2 | 4 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (human) | Rho cDNA clone 12,h12 |
| 3 | I, R, S, T (A, B, C, D) | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile | non-polymer | 460.5 | 4 | Chemie (XPW) | |||
| 4 | J, L, N, P (E, F, G, H) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | K, M, O, Q (E, F, G, H) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) |
Sequence modifications
A, B, C, D: 1 - 871 (UniProt: Q9HBA0)
| PDB | External Database | Details |
|---|---|---|
| Glu 872 | - | expression tag |
| Asn 873 | - | expression tag |
| Ser 874 | - | expression tag |
| Leu 875 | - | expression tag |
| Glu 876 | - | expression tag |
| Val 877 | - | expression tag |
| Leu 878 | - | expression tag |
| Phe 879 | - | expression tag |
| Gln 880 | - | expression tag |
| Gly 881 | - | expression tag |
| Pro 882 | - | expression tag |
| Asp 883 | - | expression tag |
| Tyr 884 | - | expression tag |
| Lys 885 | - | expression tag |
| Asp 886 | - | expression tag |
| Asp 887 | - | expression tag |
| Asp 888 | - | expression tag |
| Asp 889 | - | expression tag |
| Lys 890 | - | expression tag |
| Ala 891 | - | expression tag |
| His 892 | - | expression tag |
| His 893 | - | expression tag |
| His 894 | - | expression tag |
| His 895 | - | expression tag |
| His 896 | - | expression tag |
| His 897 | - | expression tag |
| His 898 | - | expression tag |
| His 899 | - | expression tag |
| His 900 | - | expression tag |
| His 901 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 495427.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3712.1 | |
| All* | Total formula weight | 499140.0 |
