7TX6

Cryo-EM structure of the human reduced folate carrier in complex with methotrexate

Summary for 7TX6

Entry DOI	10.2210/pdb7tx6/pdb
EMDB information	26155 26156
Descriptor	Reduced folate transporter,Soluble cytochrome b562, METHOTREXATE, Digitonin (3 entities in total)
Functional Keywords	transporter, reduced folate carrier, slc19a1, transport protein, anion exchanger
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	76480.95
Authors	Wright, N.J.,Fedor, J.G.,Lee, S.-Y. (deposition date: 2022-02-07, release date: 2022-09-21, Last modification date: 2024-03-13)
Primary citation	Wright, N.J.,Fedor, J.G.,Zhang, H.,Jeong, P.,Suo, Y.,Yoo, J.,Hong, J.,Im, W.,Lee, S.Y. Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609:1056-1062, 2022 Cited by PubMed: 36071163 DOI: 10.1038/s41586-022-05168-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation