8FC9

Cryo-EM structure of the human TRPV4 - RhoA, apo condition

Summary for 8FC9

• Entry DOI: 10.2210/pdb8fc9/pdb
• EMDB information: 28977
• Descriptor: Transient receptor potential cation channel subfamily V member 4, Transforming protein RhoA, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: trpv4, rhoa, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 497297.84

Authors

Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12)

• Primary citation: Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y.; TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.; Nat Commun, 14:3732-3732, 2023; PubMed: 37353484; DOI: 10.1038/s41467-023-39345-0

Experimental method

ELECTRON MICROSCOPY (3.75 Å)