7SQE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sqe by Molmil](/molmil-images/mine/7sqe) | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with Jun9-84-3 inhibitor | 分子名称: | (1R)-N-[(1H-indol-3-yl)methyl]-N-methyl-1-(naphthalen-1-yl)ethan-1-amine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Osipiuk, J, Tesar, C, Endres, M, Wang, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-11-05 | 公開日 | 2021-11-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Papain-Like Protease of SARS CoV-2, C111S mutant, in complex with Jun9-84-3 inhibitor To be Published
|
|
1XCC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xcc by Molmil](/molmil-images/mine/1xcc) | 1-Cys peroxidoxin from Plasmodium Yoelli | 分子名称: | 1-Cys peroxiredoxin | 著者 | Vedadi, M, Sharma, S, Houston, S, Lew, J, Wasney, G, Amani, M, Xu, X, Bray, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Hui, R, Bochkarev, A, Structural Genomics Consortium (SGC) | 登録日 | 2004-09-01 | 公開日 | 2004-11-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
|
|
6P4H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p4h by Molmil](/molmil-images/mine/6p4h) | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2) | 分子名称: | 18S rRNA, IAPV-IRES, RACK1, ... | 著者 | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | 登録日 | 2019-05-27 | 公開日 | 2019-09-18 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
|
|
7SZ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sz7 by Molmil](/molmil-images/mine/7sz7) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
7SZ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sz1 by Molmil](/molmil-images/mine/7sz1) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
7SYD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7syd by Molmil](/molmil-images/mine/7syd) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
7SZ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sz5 by Molmil](/molmil-images/mine/7sz5) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
5A2J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5a2j by Molmil](/molmil-images/mine/5a2j) | Crystal structure of scFv-SM3 in complex with the naked peptide APDTRP | 分子名称: | 1,2-ETHANEDIOL, SCFV-SM3, THE NAKED PEPTIDE APDTRP | 著者 | Martinez-Saez, N, Castro-Lopez, J, Valero-Gonzalez, J, Madariaga, D, Companon, I, Somovilla, V.J, Salvado, M, Asensio, J.L, Jimenez-Barbero, J, Avenoza, A, Busto, J.H, Bernardes, G.J.L, Peregrina, J.M, Hurtado-Guerrero, R, Corzana, F. | 登録日 | 2015-05-20 | 公開日 | 2015-06-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an Anti-Muc1 Antibody. Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
7SYE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sye by Molmil](/molmil-images/mine/7sye) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
7ZXU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zxu by Molmil](/molmil-images/mine/7zxu) | SARS-CoV-2 Omicron BA.4/5 RBD in complex with Beta-27 Fab and C1 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-27 heavy chain, Beta-27 light chain, ... | 著者 | Huo, J, Zhou, D, Ren, J, Stuart, D.I. | 登録日 | 2022-05-23 | 公開日 | 2022-06-29 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum. Cell, 185, 2022
|
|
7SZ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sz0 by Molmil](/molmil-images/mine/7sz0) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
|
|
6P4G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p4g by Molmil](/molmil-images/mine/6p4g) | Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | 分子名称: | 18S rRNA, IAPV-IRES, RACK1, ... | 著者 | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | 登録日 | 2019-05-27 | 公開日 | 2019-09-18 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
|
|
6P5I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6p5i by Molmil](/molmil-images/mine/6p5i) | Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | 著者 | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | 登録日 | 2019-05-30 | 公開日 | 2019-09-18 | 最終更新日 | 2020-02-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
|
|
8HQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hqg by Molmil](/molmil-images/mine/8hqg) | |
6PLX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6plx by Molmil](/molmil-images/mine/6plx) | CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, desensitized state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-01-06 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
|
|
6PMO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pmo by Molmil](/molmil-images/mine/6pmo) | |
6PNY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6pny by Molmil](/molmil-images/mine/6pny) | X-ray Structure of Flpp3 | 分子名称: | Flpp3 | 著者 | Zook, J.D, Shekhar, M, Hansen, D.T, Conrad, C, Grant, T.D, Gupta, C, White, T, Barty, A, Basu, S, Zhao, Y, Zatsepin, N.A, Ishchenko, A, Batyuk, A, Gati, C, Li, C, Galli, L, Coe, J, Hunter, M, Liang, M, Weierstall, U, Nelson, G, James, D, Stauch, B, Craciunescu, F, Thifault, D, Liu, W, Cherezov, V, Singharoy, A, Fromme, P. | 登録日 | 2019-07-03 | 公開日 | 2020-02-26 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia. Structure, 28, 2020
|
|
1TKT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1tkt by Molmil](/molmil-images/mine/1tkt) | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW426318 | 分子名称: | 6-CHLORO-4-(CYCLOHEXYLOXY)-3-PROPYLQUINOLIN-2(1H)-ONE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Hopkins, A.L, Ren, J, Stuart, D.I, Stammers, D.K. | 登録日 | 2004-06-09 | 公開日 | 2004-12-07 | 最終更新日 | 2018-01-31 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1. J.Med.Chem., 47, 2004
|
|
6XKI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xki by Molmil](/molmil-images/mine/6xki) | Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog | 分子名称: | (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ... | 著者 | Liang, J, Naineni, S.K, Pelletier, J, Nagar, B. | 登録日 | 2020-06-26 | 公開日 | 2021-01-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A. Cell Chem Biol, 28, 2021
|
|
7AGB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7agb by Molmil](/molmil-images/mine/7agb) | Protease Sapp1p from Candida parapsilosis in complex with KB70 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, Candidapepsin, ... | 著者 | Dostal, J, Heidingsfeld, O, Brynda, J. | 登録日 | 2020-09-22 | 公開日 | 2021-04-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis . J Enzyme Inhib Med Chem, 36, 2021
|
|
7AGE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7age by Molmil](/molmil-images/mine/7age) | |
6MFG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mfg by Molmil](/molmil-images/mine/6mfg) | HLA-DQ2-glia-alpha1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DQ alpha 1 chain, ... | 著者 | Petersen, J, Ciacchi, L, Rossjohn, J. | 登録日 | 2018-09-10 | 公開日 | 2018-11-21 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes. J. Biol. Chem., 294, 2019
|
|
7AGD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7agd by Molmil](/molmil-images/mine/7agd) | Protease Sapp1p from Candida parapsilosis in complex with KB75 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Candidapepsin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dostal, J, Heidingsfeld, O, Brynda, J. | 登録日 | 2020-09-22 | 公開日 | 2021-04-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis . J Enzyme Inhib Med Chem, 36, 2021
|
|
8DKU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8dku by Molmil](/molmil-images/mine/8dku) | CryoEM structure of the A. aeolicus WzmWzt transporter bound to the native O antigen | 分子名称: | 6-deoxy-3-O-methyl-alpha-D-mannopyranose-(1-3)-beta-D-rhamnopyranose-(1-2)-alpha-D-rhamnopyranose, ABC transporter, Transport permease protein | 著者 | Spellmon, N, Muszynski, A, Vlach, J, Zimmer, J. | 登録日 | 2022-07-06 | 公開日 | 2022-09-21 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for polysaccharide recognition and modulated ATP hydrolysis by the O antigen ABC transporter. Nat Commun, 13, 2022
|
|
7AGC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7agc by Molmil](/molmil-images/mine/7agc) | Protease Sapp1p from Candida parapsilosis in complex with KB74 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Candidapepsin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Dostal, J, Heidingsfeld, O, Brynda, J. | 登録日 | 2020-09-22 | 公開日 | 2021-04-21 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis . J Enzyme Inhib Med Chem, 36, 2021
|
|