7AGD

Protease Sapp1p from Candida parapsilosis in complex with KB75

Summary for 7AGD

• Entry DOI: 10.2210/pdb7agd/pdb
• Descriptor: Candidapepsin, KB75, PENTAETHYLENE GLYCOL, ... (9 entities in total)
• Functional Keywords: secreted aspartic protease, virulence factor, candidiasis, peptidomimetic inhibitors, antibiotic
• Biological source: Candida parapsilosis (Yeast); More
• Total number of polymer chains: 8
• Total formula weight: 148106.10

Authors

Dostal, J.,Heidingsfeld, O.,Brynda, J. (deposition date: 2020-09-22, release date: 2021-04-21, Last modification date: 2024-01-31)

• Primary citation: Dostal, J.,Brynda, J.,Vankova, L.,Zia, S.R.,Pichova, I.,Heidingsfeld, O.,Lepsik, M.; Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis .; J Enzyme Inhib Med Chem, 36:914-921, 2021; PubMed: 33843395; DOI: 10.1080/14756366.2021.1906664

Experimental method

X-RAY DIFFRACTION (1.8 Å)