Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1)

This is a large structure.

Summary for 6P5I

Related6P4G 6P4H
EMDB information20248 20249 20255
Descriptor18S rRNA, uS2, eS1, ... (81 entities in total)
Functional Keywordsisraeli acute paralysis virus, internal ribosome entry site, ires, small ribosomal subunit, 40s, large ribosomal subunit, 60s, 80s, ribosome
Biological sourceIsraeli acute paralysis virus
Total number of polymer chains81
Total molecular weight3411882.11
Acosta-Reyes, F.J.,Neupane, R.,Frank, J.,Fernandez, I.S. (deposition date: 2019-05-30, release date: 2019-09-18, Last modification date: 2020-02-26)
Primary citation
Acosta-Reyes, F.,Neupane, R.,Frank, J.,Fernandez, I.S.
The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs.
Embo J., 38:e102226-e102226, 2019
PubMed: 31609474 (PDB entries with the same primary citation)
DOI: 10.15252/embj.2019102226
MImport into Mendeley
Experimental method

Structure validation

Ramachandran outliersSidechain outliersRNA backbone 0.5% 3.2% 0.45MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-10-21