7SZ7

Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation

Summary for 7SZ7

• Entry DOI: 10.2210/pdb7sz7/pdb
• Related: 7SZ5
• EMDB information: 25561 25563
• Descriptor: Epidermal growth factor receptor, Transforming growth factor alpha (2 entities in total)
• Functional Keywords: receptor tyrosine kinases, epidermal growth factor receptor, signaling protein, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 279987.15

Authors

Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. (deposition date: 2021-11-25, release date: 2021-12-15)

• Primary citation: Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J.; A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.; Elife, 10:-, 2021; PubMed: 34846302; DOI: 10.7554/eLife.73218

Experimental method

ELECTRON MICROSCOPY (3.4 Å)