7SZ7
Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Epidermal growth factor receptor | polymer | 1210 | 134433.3 | 2 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | C, D | Transforming growth factor alpha | polymer | 50 | 5560.2 | 2 | UniProt (P01135) In PDB | Homo sapiens (Human) | TGF-alpha,EGF-like TGF,ETGF,TGF type 1 |
Sequence modifications
A, B: -23 - 1186 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Asn 232 | Asp 256 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 279987.1 | |
| All* | Total formula weight | 279987.1 |
