7SYD

Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation

Summary for 7SYD

Entry DOI	10.2210/pdb7syd/pdb
EMDB information	25522
Descriptor	Epidermal growth factor receptor, Epidermal growth factor (2 entities in total)
Functional Keywords	receptor tyrosine kinases, epidermal growth factor receptor, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	281324.71
Authors	Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. (deposition date: 2021-11-24, release date: 2021-12-22)
Primary citation	Huang, Y.,Ognjenovic, J.,Karandur, D.,Miller, K.,Merk, A.,Subramaniam, S.,Kuriyan, J. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10:-, 2021 Cited by PubMed: 34846302 DOI: 10.7554/eLife.73218 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation