6IHJ
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7CFK
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2IJG
| Crystal Structure of cryptochrome 3 from Arabidopsis thaliana | 分子名称: | 5,10-METHENYL-6,7,8-TRIHYDROFOLIC ACID, Cryptochrome DASH, chloroplast/mitochondrial, ... | 著者 | Huang, Y, Deisenhofer, J. | 登録日 | 2006-09-29 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity Proc.Natl.Acad.Sci.Usa, 103, 2006
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5WQA
| Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K | 分子名称: | 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y, Zhang, T, Zheng, X, Yin, S, Luo, H.B. | 登録日 | 2016-11-24 | 公開日 | 2017-02-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata Biochem. Pharmacol., 130, 2017
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7CWF
| Crystal structure of PDE8A catalytic domain in complex with 2c | 分子名称: | 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWG
| Crystal structure of PDE8A catalytic domain in complex with 3a | 分子名称: | 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-28 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWA
| Crystal structure of PDE8A catalytic domain in complex with clofarabine | 分子名称: | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | 著者 | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | 登録日 | 2020-08-27 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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6LNK
| Candida albicans Fructose-1,6-bisphosphate aldolase | 分子名称: | 1,2-ETHANEDIOL, Fructose-bisphosphate aldolase, ZINC ION | 著者 | Huang, Y, Cao, H, Ren, Y, Wan, J. | 登録日 | 2019-12-30 | 公開日 | 2020-12-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.639 Å) | 主引用文献 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022
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7VRF
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7C9Q
| Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP | 分子名称: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION | 著者 | Huang, Y, Li, R, Wan, J. | 登録日 | 2020-06-07 | 公開日 | 2021-06-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.878 Å) | 主引用文献 | Crystal structure of Human liver fructose-1,6-bisphoaphatase complex with Mg2+ and AMP To Be Published
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2MT8
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6KBB
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7SZ7
| Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYE
| Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ0
| Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ5
| Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha "tips-separated" conformation | 分子名称: | Epidermal growth factor receptor, Transforming growth factor alpha | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ1
| Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-25 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYD
| Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | 分子名称: | Epidermal growth factor, Epidermal growth factor receptor | 著者 | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | 登録日 | 2021-11-24 | 公開日 | 2021-12-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7UG0
| TBOA-bound GltPh RSMR mutant in IFS state | 分子名称: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-23 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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7UGJ
| TBOA-bound GltPh RSMR mutant in OFS state | 分子名称: | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-24 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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7UGV
| Asp-bound GltPh RSMR mutant in IFS-A2 state | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19 F NMR and Cryo-EM. J.Am.Chem.Soc., 145, 2023
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7UGX
| Asp-bound GltPh RSMR mutant in IFS-B1 state | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19 F NMR and Cryo-EM. J.Am.Chem.Soc., 145, 2023
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7UH3
| Asp-bound GltPh RSMR mutant in iOFS state | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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7UH6
| Asp-bound GltPh RSMR mutant in IFS-B2 state | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-25 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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7UGD
| Asp-bound GltPh RSMR mutant in IFS-A1 state | 分子名称: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | 著者 | Huang, Y, Boudker, O. | 登録日 | 2022-03-24 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-10 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by 19F NMR and Cryo-EM J.Am.Chem.Soc., 145, 2023
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