7CWF

Crystal structure of PDE8A catalytic domain in complex with 2c

Summary for 7CWF

• Entry DOI: 10.2210/pdb7cwf/pdb
• Descriptor: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: camp-specific, hydrolase, selective pde8a inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 39520.45

Authors

Huang, Y.,Wu, X.-N.,Zhou, Q.,Wu, Y.,Luo, H.-B. (deposition date: 2020-08-28, release date: 2021-09-01, Last modification date: 2023-11-29)

• Primary citation: Huang, Y.,Wu, X.N.,Zhou, Q.,Wu, Y.,Zheng, D.,Li, Z.,Guo, L.,Luo, H.B.; Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.; J.Med.Chem., 63:15852-15863, 2020; PubMed: 33291877; DOI: 10.1021/acs.jmedchem.0c01573

Experimental method

X-RAY DIFFRACTION (2.8 Å)