6LNK

Candida albicans Fructose-1,6-bisphosphate aldolase

Summary for 6LNK

• Entry DOI: 10.2210/pdb6lnk/pdb
• Descriptor: Fructose-bisphosphate aldolase, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: aldolase, lyase
• Biological source: Candida albicans SC5314 (Yeast)
• Total number of polymer chains: 2
• Total formula weight: 80439.24

Authors

Huang, Y.,Cao, H.,Ren, Y.,Wan, J. (deposition date: 2019-12-30, release date: 2020-12-30, Last modification date: 2023-11-22)

• Primary citation: Wen, W.,Cao, H.,Huang, Y.,Tu, J.,Wan, C.,Wan, J.,Han, X.,Chen, H.,Liu, J.,Rao, L.,Su, C.,Peng, C.,Sheng, C.,Ren, Y.; Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.; J.Med.Chem., 65:2656-2674, 2022; DOI: 10.1021/acs.jmedchem.1c02102

Experimental method

X-RAY DIFFRACTION (2.639 Å)