5WQA

Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K

Summary for 5WQA

Entry DOI	10.2210/pdb5wqa/pdb
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, ZINC ION, ... (5 entities in total)
Functional Keywords	natural pde4 inhibtor, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Apical cell membrane : Q08499
Total number of polymer chains	2
Total formula weight	78270.06
Authors	Huang, Y.,Zhang, T.,Zheng, X.,Yin, S.,Luo, H.B. (deposition date: 2016-11-24, release date: 2017-02-22, Last modification date: 2023-11-08)
Primary citation	Huang, Y.,Liu, X.,Wu, D.,Tang, G.,Lai, Z.,Zheng, X.,Yin, S.,Luo, H.B. The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata Biochem. Pharmacol., 130:51-59, 2017 Cited by PubMed: 28159622 DOI: 10.1016/j.bcp.2017.01.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation