7CWA

Crystal structure of PDE8A catalytic domain in complex with clofarabine

Summary for 7CWA

Entry DOI	10.2210/pdb7cwa/pdb
Descriptor	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pde8a inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39483.41
Authors	Huang, Y.,Wu, X.-N.,Zhou, Q.,Wu, Y.,Luo, H.-B. (deposition date: 2020-08-27, release date: 2021-09-01, Last modification date: 2023-11-29)
Primary citation	Huang, Y.,Wu, X.N.,Zhou, Q.,Wu, Y.,Zheng, D.,Li, Z.,Guo, L.,Luo, H.B. Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63:15852-15863, 2020 Cited by PubMed: 33291877 DOI: 10.1021/acs.jmedchem.0c01573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation