7CWA

Crystal structure of PDE8A catalytic domain in complex with clofarabine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGrtNsF

Chain	Residue	Details
A	HIS596-PHE607

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18983167","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ECM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ECN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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