7DA5
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![BU of 7da5 by Molmil](/molmil-images/mine/7da5) | Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation. | 分子名称: | Basigin, Monocarboxylate transporter 1 | 著者 | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | 登録日 | 2020-10-14 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184, 2021
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4WQ0
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8TB7
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![BU of 8tb7 by Molmil](/molmil-images/mine/8tb7) | Cryo-EM Structure of GPR61- | 分子名称: | 6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide, Fab hinge-binding nanobody, Fab24 BAK5 heavy chain, ... | 著者 | Lees, J.A, Dias, J.M, Han, S. | 登録日 | 2023-06-28 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism. Nat Commun, 14, 2023
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8TDW
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![BU of 8tdw by Molmil](/molmil-images/mine/8tdw) | ssRNA bound SAMHD1 T open | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*C)-3'), ... | 著者 | Sung, M, Huynh, K, Han, S. | 登録日 | 2023-07-05 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
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8TDV
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![BU of 8tdv by Molmil](/molmil-images/mine/8tdv) | ssRNA bound SAMHD1 T closed | 分子名称: | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, RNA (5'-R(P*CP*CP*GP*AP*CP*CP*C)-3'), ... | 著者 | Sung, M, Huynh, K, Han, S. | 登録日 | 2023-07-05 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1. Nucleic Acids Res., 51, 2023
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7D99
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![BU of 7d99 by Molmil](/molmil-images/mine/7d99) | human potassium-chloride co-transporter KCC4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, POTASSIUM ION, ... | 著者 | Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J. | 登録日 | 2020-10-12 | 公開日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv, 6, 2020
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7D8Z
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![BU of 7d8z by Molmil](/molmil-images/mine/7d8z) | human potassium-chloride co-transporter KCC2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, potassium-chloride cotransporter 2 | 著者 | Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J. | 登録日 | 2020-10-11 | 公開日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv, 6, 2020
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7D90
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![BU of 7d90 by Molmil](/molmil-images/mine/7d90) | human potassium-chloride co-transporter KCC3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, potassium-chloride cotransporter 3 | 著者 | Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J. | 登録日 | 2020-10-12 | 公開日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures and an activation mechanism of human potassium-chloride cotransporters. Sci Adv, 6, 2020
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3TUD
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![BU of 3tud by Molmil](/molmil-images/mine/3tud) | Crystal structure of SYK kinase domain with N-(4-methyl-3-(8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-3-(trifluoromethyl)benzamide | 分子名称: | N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide, Tyrosine-protein kinase SYK | 著者 | Lovering, F, McDonald, J, Whitlock, G, Glossop, P, Phillips, C, Sabnis, Y, Ryan, M, Fitz, L, Lee, J, Chang, J.S, Han, S, Kurumbail, R, Thorarenson, A. | 登録日 | 2011-09-16 | 公開日 | 2012-08-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80, 2012
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3TUC
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![BU of 3tuc by Molmil](/molmil-images/mine/3tuc) | Crystal structure of SYK kinase domain with 1-benzyl-N-(5-(6,7-dimethoxyquinolin-4-yloxy)pyridin-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide | 分子名称: | 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide, Tyrosine-protein kinase SYK | 著者 | Lovering, F, McDonald, J, Whitlock, G, Glossop, P, Phillips, C, Sabnis, Y, Ryan, M, Fitz, L, Lee, J, Chang, J.S, Han, S, Kurumbail, R, Thorarenson, A. | 登録日 | 2011-09-16 | 公開日 | 2012-08-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of Type-II Inhibitors Using Kinase Structures. Chem.Biol.Drug Des., 80, 2012
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7RCU
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![BU of 7rcu by Molmil](/molmil-images/mine/7rcu) | Synthetic Max homodimer mimic in complex with DNA | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... | 著者 | Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. | 登録日 | 2021-07-08 | 公開日 | 2022-09-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
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9B1R
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![BU of 9b1r by Molmil](/molmil-images/mine/9b1r) | Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1 | 著者 | Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C. | 登録日 | 2024-03-13 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana. Sci Rep, 14, 2024
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7WX5
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![BU of 7wx5 by Molmil](/molmil-images/mine/7wx5) | a Legionella acetyltransferase effector VipF | 分子名称: | ACETYL COENZYME *A, N-acetyltransferase | 著者 | Chen, T.T, Lin, Y.L, Zhang, S.J, Han, A.D. | 登録日 | 2022-02-14 | 公開日 | 2023-02-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.392 Å) | 主引用文献 | Structural basis for the acetylation mechanism of the Legionella effector VipF. Acta Crystallogr D Struct Biol, 78, 2022
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7WX7
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![BU of 7wx7 by Molmil](/molmil-images/mine/7wx7) | complex of a legionella acetyltransferase VipF and COA/ACO | 分子名称: | ACETYL COENZYME *A, COENZYME A, N-acetyltransferase | 著者 | Chen, T.T, Lin, Y.L, Zhang, S.J, Han, A.D. | 登録日 | 2022-02-14 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.781 Å) | 主引用文献 | Structural basis for the acetylation mechanism of the Legionella effector VipF. Acta Crystallogr D Struct Biol, 78, 2022
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8JD6
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![BU of 8jd6 by Molmil](/molmil-images/mine/8jd6) | Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ... | 著者 | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-05-12 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD0
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![BU of 8jd0 by Molmil](/molmil-images/mine/8jd0) | Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of NAM563 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, CHOLESTEROL, ... | 著者 | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-05-12 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD5
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![BU of 8jd5 by Molmil](/molmil-images/mine/8jd5) | Cryo-EM structure of Gi1-bound mGlu2-mGlu4 heterodimer | 分子名称: | 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine, ... | 著者 | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Zhao, Q, Wu, B. | 登録日 | 2023-05-12 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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8JD3
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![BU of 8jd3 by Molmil](/molmil-images/mine/8jd3) | Cryo-EM structure of Gi1-bound mGlu2-mGlu3 heterodimer | 分子名称: | 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, CHOLESTEROL, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, ... | 著者 | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-05-12 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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4ZQS
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6USF
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![BU of 6usf by Molmil](/molmil-images/mine/6usf) | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor with varenicline in complex with anti-BRIL synthetic antibody BAK5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, ... | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | 登録日 | 2019-10-26 | 公開日 | 2020-04-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins. Nat Commun, 11, 2020
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7E9G
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![BU of 7e9g by Molmil](/molmil-images/mine/7e9g) | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu2 | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 1-butyl-3-chloranyl-4-(4-phenylpiperidin-1-yl)pyridin-2-one, DN13, ... | 著者 | Lin, S, Han, S, Zhao, Q, Wu, B. | 登録日 | 2021-03-04 | 公開日 | 2021-06-23 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4. Nature, 594, 2021
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7E9H
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![BU of 7e9h by Molmil](/molmil-images/mine/7e9h) | Cryo-EM structure of Gi-bound metabotropic glutamate receptor mGlu4 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-3, ... | 著者 | Lin, S, Han, S, Zhao, Q, Wu, B. | 登録日 | 2021-03-04 | 公開日 | 2021-06-23 | 最終更新日 | 2021-07-07 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of G i -bound metabotropic glutamate receptors mGlu2 and mGlu4. Nature, 594, 2021
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6WWZ
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![BU of 6wwz by Molmil](/molmil-images/mine/6wwz) | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein | 分子名称: | C-C chemokine receptor type 6,C-C chemokine receptor type 6, C-C motif chemokine 20, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Wasilko, D.J, Johnson, Z.L, Ammirati, M, Han, S, Wu, H. | 登録日 | 2020-05-09 | 公開日 | 2020-06-24 | 最終更新日 | 2020-07-01 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nat Commun, 11, 2020
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5CWE
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![BU of 5cwe by Molmil](/molmil-images/mine/5cwe) | Structure of CYP107L2 from Streptomyces avermitilis with lauric acid | 分子名称: | Cytochrome P450 hydroxylase, GLYCEROL, LAURIC ACID, ... | 著者 | Pham, T.-V, Han, S.-H, Kim, J.-H, Kim, D.-H, Kang, L.-W. | 登録日 | 2015-07-28 | 公開日 | 2016-08-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure of CYP107L2 from Streptomyces avermitilis with lauric acid To Be Published
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8JD1
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![BU of 8jd1 by Molmil](/molmil-images/mine/8jd1) | Cryo-EM structure of mGlu2-mGlu3 heterodimer in Rco state | 分子名称: | CHOLESTEROL, GLUTAMIC ACID, Metabotropic glutamate receptor 2,Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | 著者 | Wang, X, Wang, M, Xu, T, Feng, Y, Han, S, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-05-12 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into dimerization and activation of the mGlu2-mGlu3 and mGlu2-mGlu4 heterodimers. Cell Res., 33, 2023
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