7RCU

Synthetic Max homodimer mimic in complex with DNA

Summary for 7RCU

• Entry DOI: 10.2210/pdb7rcu/pdb
• Descriptor: Protein max, DNA (5'-D(*A*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*A)-3'), DNA (5'-D(*G*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*A)-3'), ... (8 entities in total)
• Functional Keywords: synthetic protein, complex, transcription factor mimic, dna binding protein, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 24
• Total formula weight: 90424.62

Authors

Speltz, T.,Qiao, Z.,Shangguan, S.,Fanning, S.,Greene, J.,Moellering, R. (deposition date: 2021-07-08, release date: 2022-09-14, Last modification date: 2024-04-17)

• Primary citation: Speltz, T.E.,Qiao, Z.,Swenson, C.S.,Shangguan, X.,Coukos, J.S.,Lee, C.W.,Thomas, D.M.,Santana, J.,Fanning, S.W.,Greene, G.L.,Moellering, R.E.; Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains.; Nat.Biotechnol., 41:541-551, 2023; PubMed: 36302987; DOI: 10.1038/s41587-022-01504-x

Experimental method

X-RAY DIFFRACTION (2.69 Å)