7DA5

Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation.

Summary for 7DA5

• Entry DOI: 10.2210/pdb7da5/pdb
• Related: 6LYY 6LZ0 7CKO 7CKR
• EMDB information: 30623
• Descriptor: Monocarboxylate transporter 1, Basigin (2 entities in total)
• Functional Keywords: proton-coupled monocarboxylate transporter, mct1, basigin, azd3965, single particle cryo-em, latate transporter, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83246.80

Authors

Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Lei, J.,Yan, C. (deposition date: 2020-10-14, release date: 2020-12-23, Last modification date: 2024-03-27)

• Primary citation: Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C.; Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.; Cell, 184:370-, 2021; PubMed: 33333023; DOI: 10.1016/j.cell.2020.11.043

Experimental method

ELECTRON MICROSCOPY (3.3 Å)