7CKR
Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation.
Summary for 7CKR
Entry DOI | 10.2210/pdb7ckr/pdb |
Related | 6LYY 6LZ0 7CKO |
EMDB information | 30019 30020 30389 30391 |
Descriptor | Monocarboxylate transporter 1, Basigin, 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid (3 entities in total) |
Functional Keywords | proton-coupled monocarboxylate transporter, mct1, basigin, anti-cancer drug candidate, azd3965, bay-8002, 7acc2, single particle cryo-em, latate transporter, transport protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 83663.64 |
Authors | |
Primary citation | Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates. Cell, 184:370-, 2021 Cited by PubMed: 33333023DOI: 10.1016/j.cell.2020.11.043 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3 Å) |
Structure validation
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