7CKR

Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation.

Summary for 7CKR

• Entry DOI: 10.2210/pdb7ckr/pdb
• Related: 6LYY 6LZ0 7CKO
• EMDB information: 30019 30020 30389 30391
• Descriptor: Monocarboxylate transporter 1, Basigin, 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid (3 entities in total)
• Functional Keywords: proton-coupled monocarboxylate transporter, mct1, basigin, anti-cancer drug candidate, azd3965, bay-8002, 7acc2, single particle cryo-em, latate transporter, transport protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 83663.64

Authors

Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Lei, J.,Yan, C. (deposition date: 2020-07-18, release date: 2020-12-23, Last modification date: 2024-03-27)

• Primary citation: Wang, N.,Jiang, X.,Zhang, S.,Zhu, A.,Yuan, Y.,Xu, H.,Lei, J.,Yan, C.; Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.; Cell, 184:370-, 2021; PubMed: 33333023; DOI: 10.1016/j.cell.2020.11.043

Experimental method

ELECTRON MICROSCOPY (3 Å)