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PDB: 85 件
1VIN
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BOVINE CYCLIN A3
分子名称: CYCLIN A
著者Noble, M.E.M, Endicott, J.A.E, Brown, N.R.
登録日1996-03-15
公開日1996-08-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of cyclin A.
Structure, 3, 1995
3BHT
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Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 3
分子名称: 4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ...
著者Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L.
登録日2007-11-29
公開日2008-02-12
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
Cancer Res., 67, 2007
3BHV
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Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B
分子名称: 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, Cell division protein kinase 2, Cyclin-A2, ...
著者Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L.
登録日2007-11-29
公開日2008-02-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
Cancer Res., 67, 2007
3BHU
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Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
分子名称: 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, Cell division protein kinase 2, Cyclin-A2, ...
著者Echalier, A, Bettayeb, K, Ferandin, Y, Lozach, O, Clement, M, Valette, A, Liger, F, Marquet, B, Morris, J.C, Endicott, J.A, Joseph, B, Meijer, L.
登録日2007-11-29
公開日2008-02-12
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
Cancer Res., 67, 2007
4Y72
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Human CDK1/CyclinB1/CKS2 With Inhibitor
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-13
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC3
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CDK1/CyclinB1/CKS2 Apo
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2016-04-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC6
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CDK1/CKS1
分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
著者Brown, N.R, Korolchuk, S, Martin, M.P, Stanley, W, Moukhametzianov, R, Noble, M.E.M, Endicott, J.A.
登録日2015-02-19
公開日2015-05-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
2X5N
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Crystal Structure of the SpRpn10 VWA domain
分子名称: 26S PROTEASOME REGULATORY SUBUNIT RPN10, SULFATE ION
著者Riedinger, C, Boehringer, J, Trempe, J.-F, Lowe, E.D, Brown, N.R, Gehring, K, Noble, M.E.M, Gordon, C, Endicott, J.A.
登録日2010-02-10
公開日2010-08-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献The Structure of Rpn10 and its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12.
J.Biol.Chem., 285, 2010
2WMB
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Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, LINEAR RKLFD, ...
著者Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M.
登録日2009-06-30
公開日2010-09-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A
To be Published
2WMA
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Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin A
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIC RKLFN-NH2, CYCLIN-A2
著者Robertson, G.F, Endicott, J.A, Noble, M.E.M, McDonnell, J.M.
登録日2009-06-30
公開日2010-09-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and Thermodynamic Consequences of Cyclization of Peptide Ligands for the Recruitment Site of Cyclin A
To be Published
1Z96
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Crystal structure of the Mud1 UBA domain
分子名称: UBA-domain protein mud1
著者Trempe, J.-F, Brown, N.R, Lowe, E.D, Noble, M.E.M, Gordon, C, Campbell, I.D, Johnson, L.N, Endicott, J.A.
登録日2005-03-31
公開日2005-10-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain
Embo J., 24, 2005
2G9X
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Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
分子名称: 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, Cell division protein kinase 2, Cyclin-A2
著者Echalier, A, Endicott, J.A, Noble, M.E.
登録日2006-03-07
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination.
J.Am.Chem.Soc., 128, 2006
2IW8
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MONOTHIOGLYCEROL, ...
著者Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
登録日2006-06-27
公開日2006-09-06
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
2IW9
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ...
著者Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
登録日2006-06-27
公開日2006-09-06
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
2IW6
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STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR
分子名称: CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, MAGNESIUM ION, ...
著者Pratt, D.J, Bentley, J, Jewsbury, P, Boyle, F.T, Endicott, J.A, Noble, M.E.M.
登録日2006-06-26
公開日2006-09-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity.
J.Med.Chem., 49, 2006
3DDP
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BU of 3ddp by Molmil
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
分子名称: (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, Cell division protein kinase 2, Cyclin-A2
著者Echalier, A, Endicott, J.A.
登録日2008-06-06
公開日2008-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27, 2008
3TNW
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Structure of CDK2/cyclin A in complex with CAN508
分子名称: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-A2, Cyclin-dependent kinase 2, ...
著者Baumli, S, Hole, A.J, Endicott, J.A.
登録日2011-09-02
公開日2012-02-15
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3DDQ
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Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
分子名称: Cell division protein kinase 2, Cyclin-A2, MONOTHIOGLYCEROL, ...
著者Echalier, A, Endicott, J.A.
登録日2008-06-06
公開日2008-07-22
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27, 2008
1W8C
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CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2
分子名称: 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2
著者Pratt, D.J, Endicott, J.A, Noble, M.E.M.
登録日2004-09-20
公開日2006-08-30
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
J.Med.Chem., 57, 2014
3G33
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Crystal structure of CDK4/cyclin D3
分子名称: CCND3 protein, Cell division protein kinase 4
著者Takaki, T, Echalier, A, Brown, N.R, Hunt, T, Endicott, J.A, Noble, M.E.M.
登録日2009-02-01
公開日2009-03-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The structure of CDK4/cyclin D3 has implications for models of CDK activation.
Proc.Natl.Acad.Sci.USA, 106, 2009
3TNH
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CDK9/cyclin T in complex with CAN508
分子名称: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9
著者Baumli, S, Hole, A.J, Endicott, J.A.
登録日2011-09-01
公開日2012-02-15
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.202 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
3TNI
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structure of CDK9/cyclin T F241L
分子名称: Cyclin-T1, Cyclin-dependent kinase 9
著者Baumli, S, Hole, A.J, Endicott, J.A.
登録日2011-09-01
公開日2012-02-15
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.234 Å)
主引用文献The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508.
Acs Chem.Biol., 7, 2012
4EC9
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Crystal structure of full-length cdk9 in complex with cyclin t
分子名称: Cyclin-T1, Cyclin-dependent kinase 9
著者Baumli, S, Hole, A.J, Endicott, J.A.
登録日2012-03-26
公開日2012-09-12
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
4EC8
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Structure of full length CDK9 in complex with cyclinT and DRB
分子名称: Cyclin-T1, Cyclin-dependent kinase 9
著者Baumli, S, Hole, A.J, Endicott, J.A.
登録日2012-03-26
公開日2012-09-12
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献The CDK9 tail determines the reaction pathway of positive transcription elongation factor b.
Structure, 20, 2012
4HG7
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Crystal Structure of an MDM2/Nutlin-3a complex
分子名称: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
著者Noble, M.E.M, Anil, B, Riedinger, C, Endicott, J.A.
登録日2012-10-07
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.
Acta Crystallogr.,Sect.D, 69, 2013

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