1VIN

BOVINE CYCLIN A3

Summary for 1VIN

Entry DOI	10.2210/pdb1vin/pdb
Descriptor	CYCLIN A (2 entities in total)
Functional Keywords	cyclin, cell cycle, kinase-regulatory-subunit, binding protein
Biological source	Bos taurus (cattle)
Cellular location	Nucleus: P30274
Total number of polymer chains	1
Total formula weight	30831.50
Authors	Noble, M.E.M.,Endicott, J.A.E.,Brown, N.R. (deposition date: 1996-03-15, release date: 1996-08-17, Last modification date: 2024-02-14)
Primary citation	Brown, N.R.,Noble, M.E.,Endicott, J.A.,Garman, E.F.,Wakatsuki, S.,Mitchell, E.,Rasmussen, B.,Hunt, T.,Johnson, L.N. The crystal structure of cyclin A. Structure, 3:1235-1247, 1995 Cited by PubMed Abstract: Eukaryotic cell cycle progression is regulated by cyclin dependent protein kinases (CDKs) whose activity is regulated by association with cyclins and by reversible phosphorylation. Cyclins also determine the subcellular location and substrate specificity of CDKs. Cyclins exhibit diverse sequences but all share homology over a region of approximately 100 amino acids, termed the cyclin box. From the determination of the structure of cyclin A, together with results from biochemical and genetic analyses, we can identify which parts of the cyclin molecular may contribute to cyclin A structure and function. PubMed: 8591034 DOI: 10.1016/S0969-2126(01)00259-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation