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3BHU

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5

Summary for 3BHU
Entry DOI10.2210/pdb3bhu/pdb
Related3BHT 3BHV
DescriptorCell division protein kinase 2, Cyclin-A2, 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, ... (5 entities in total)
Functional Keywordsser/thr protein kinase, transferase, phosphorylation, cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, cyclin
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Nucleus : P30274
Total number of polymer chains4
Total formula weight129025.68
Authors
Echalier, A.,Bettayeb, K.,Ferandin, Y.,Lozach, O.,Clement, M.,Valette, A.,Liger, F.,Marquet, B.,Morris, J.C.,Endicott, J.A.,Joseph, B.,Meijer, L. (deposition date: 2007-11-29, release date: 2008-02-12, Last modification date: 2017-10-25)
Primary citationBettayeb, K.,Tirado, O.M.,Marionneau-Lambot, S.,Ferandin, Y.,Lozach, O.,Morris, J.C.,Mateo-Lozano, S.,Drueckes, P.,Kubbutat, M.H.,Liger, F.,Marquet, B.,Joseph, B.,Echalier, A.,Endicott, J.A.,Notario, V.,Meijer, L.
Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases
Cancer Res., 67:8325-8334, 2007
Cited by
PubMed: 17804748
DOI: 10.1158/0008-5472.CAN-07-1826
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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