3BHV

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B

Summary for 3BHV

• Entry DOI: 10.2210/pdb3bhv/pdb
• Related: 3BHT 3BHU
• Descriptor: Cell division protein kinase 2, Cyclin-A2, 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol, ... (6 entities in total)
• Functional Keywords: ser/thr protein kinase, transferase, phosphorylation, cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, cyclin
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P30274
• Total number of polymer chains: 4
• Total formula weight: 129398.12

Authors

Echalier, A.,Bettayeb, K.,Ferandin, Y.,Lozach, O.,Clement, M.,Valette, A.,Liger, F.,Marquet, B.,Morris, J.C.,Endicott, J.A.,Joseph, B.,Meijer, L. (deposition date: 2007-11-29, release date: 2008-02-12, Last modification date: 2011-07-13)

• Primary citation: Bettayeb, K.,Tirado, O.M.,Marionneau-Lambot, S.,Ferandin, Y.,Lozach, O.,Morris, J.C.,Mateo-Lozano, S.,Drueckes, P.,Kubbutat, M.H.,Liger, F.,Marquet, B.,Joseph, B.,Echalier, A.,Endicott, J.A.,Notario, V.,Meijer, L.; Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases; Cancer Res., 67:8325-8334, 2007; PubMed: 17804748; DOI: 10.1158/0008-5472.CAN-07-1826

Experimental method

X-RAY DIFFRACTION (2.1 Å)