3BHV
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor variolin B
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cell division protein kinase 2 | polymer | 300 | 34200.6 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (human) | p33 protein kinase, CDK2 |
2 | B, D | Cyclin-A2 | polymer | 262 | 30018.6 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) In PDB | Bos taurus (cattle) | Cyclin-A |
3 | A, C | 9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol | non-polymer | 293.3 | 2 | Chemie (VAR) | |||
4 | B, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | B, D | MONOTHIOGLYCEROL | non-polymer | 108.2 | 3 | Chemie (SGM) | |||
6 | water | water | 18.0 | 889 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | EXPRESSION TAG |
Ser 0 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 128438.5 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 959.7 | |
All* | Total formula weight | 129398.1 |