3BHU
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
Summary for 3BHU
Entry DOI | 10.2210/pdb3bhu/pdb |
Related | 3BHT 3BHV |
Descriptor | Cell division protein kinase 2, Cyclin-A2, 4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine, ... (5 entities in total) |
Functional Keywords | ser/thr protein kinase, transferase, phosphorylation, cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, cyclin |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P30274 |
Total number of polymer chains | 4 |
Total formula weight | 129025.68 |
Authors | Echalier, A.,Bettayeb, K.,Ferandin, Y.,Lozach, O.,Clement, M.,Valette, A.,Liger, F.,Marquet, B.,Morris, J.C.,Endicott, J.A.,Joseph, B.,Meijer, L. (deposition date: 2007-11-29, release date: 2008-02-12, Last modification date: 2017-10-25) |
Primary citation | Bettayeb, K.,Tirado, O.M.,Marionneau-Lambot, S.,Ferandin, Y.,Lozach, O.,Morris, J.C.,Mateo-Lozano, S.,Drueckes, P.,Kubbutat, M.H.,Liger, F.,Marquet, B.,Joseph, B.,Echalier, A.,Endicott, J.A.,Notario, V.,Meijer, L. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases Cancer Res., 67:8325-8334, 2007 Cited by PubMed: 17804748DOI: 10.1158/0008-5472.CAN-07-1826 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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