3DDP
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
Summary for 3DDP
Entry DOI | 10.2210/pdb3ddp/pdb |
Related | 3DDQ |
Descriptor | Cell division protein kinase 2, Cyclin-A2, (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, ... (4 entities in total) |
Functional Keywords | ser/thr protein kinase; phosphorylation; cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, cyclin, cytoplasm, nucleus, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P30274 |
Total number of polymer chains | 4 |
Total formula weight | 130845.16 |
Authors | Echalier, A.,Endicott, J.A. (deposition date: 2008-06-06, release date: 2008-07-22, Last modification date: 2011-07-13) |
Primary citation | Bettayeb, K.,Oumata, N.,Echalier, A.,Ferandin, Y.,Endicott, J.A.,Galons, H.,Meijer, L. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene, 27:5797-5807, 2008 Cited by PubMed: 18574471DOI: 10.1038/onc.2008.191 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report