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3DDQ

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine

Summary for 3DDQ
Entry DOI10.2210/pdb3ddq/pdb
Related3DDP
DescriptorCell division protein kinase 2, Cyclin-A2, R-ROSCOVITINE, ... (5 entities in total)
Functional Keywordsser/thr protein kinase; transferase; phosphorylation; cell cycle, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, cyclin, cytoplasm, nucleus, transferase-cell cycle complex, transferase/cell cycle
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P30274
Total number of polymer chains4
Total formula weight131291.76
Authors
Echalier, A.,Endicott, J.A. (deposition date: 2008-06-06, release date: 2008-07-22, Last modification date: 2011-07-13)
Primary citationBettayeb, K.,Oumata, N.,Echalier, A.,Ferandin, Y.,Endicott, J.A.,Galons, H.,Meijer, L.
CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Oncogene, 27:5797-5807, 2008
Cited by
PubMed: 18574471
DOI: 10.1038/onc.2008.191
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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