3DDQ
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
Summary for 3DDQ
Entry DOI | 10.2210/pdb3ddq/pdb |
Related | 3DDP |
Descriptor | Cell division protein kinase 2, Cyclin-A2, R-ROSCOVITINE, ... (5 entities in total) |
Functional Keywords | ser/thr protein kinase; transferase; phosphorylation; cell cycle, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, cyclin, cytoplasm, nucleus, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P30274 |
Total number of polymer chains | 4 |
Total formula weight | 131291.76 |
Authors | Echalier, A.,Endicott, J.A. (deposition date: 2008-06-06, release date: 2008-07-22, Last modification date: 2011-07-13) |
Primary citation | Bettayeb, K.,Oumata, N.,Echalier, A.,Ferandin, Y.,Endicott, J.A.,Galons, H.,Meijer, L. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene, 27:5797-5807, 2008 Cited by PubMed: 18574471DOI: 10.1038/onc.2008.191 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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