3DDP
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cell division protein kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (Human) | p33 protein kinase |
2 | B, D | Cyclin-A2 | polymer | 268 | 30847.5 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) In PDB | Bos taurus (Bovine) | Cyclin-A |
3 | A, C | (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol | non-polymer | 431.5 | 2 | Chemie (RC8) | |||
4 | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
B, D: 171 - 432 (UniProt: P30274)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | EXPRESSION TAG |
PDB | External Database | Details |
---|---|---|
His 433 | - | EXPRESSION TAG |
His 434 | - | EXPRESSION TAG |
His 435 | - | EXPRESSION TAG |
His 436 | - | EXPRESSION TAG |
His 437 | - | EXPRESSION TAG |
His 438 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 129982.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 863.1 | |
All* | Total formula weight | 130845.2 |