1P7M
| SOLUTION STRUCTURE AND BASE PERTURBATION STUDIES REVEAL A NOVEL MODE OF ALKYLATED BASE RECOGNITION BY 3-METHYLADENINE DNA GLYCOSYLASE I | Descriptor: | 3-METHYL-3H-PURIN-6-YLAMINE, DNA-3-methyladenine glycosylase I, ZINC ION | Authors: | Cao, C, Kwon, K, Jiang, Y.L, Drohat, A.C, Stivers, J.T. | Deposit date: | 2003-05-02 | Release date: | 2003-11-25 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I J.Biol.Chem., 278, 2003
|
|
8YRG
| CryoEM structure of fospropofol-bound MRGPRX4-Gq complex | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2024-03-21 | Release date: | 2024-05-22 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.14 Å) | Cite: | MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Sci Transl Med, 16, 2024
|
|
7S8O
| CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | Descriptor: | (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | Deposit date: | 2021-09-18 | Release date: | 2021-11-17 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
|
|
7S8L
| CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14 | Descriptor: | Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | Deposit date: | 2021-09-18 | Release date: | 2021-11-17 | Last modified: | 2024-10-23 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
|
|
7S8M
| CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 | Descriptor: | Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | Deposit date: | 2021-09-18 | Release date: | 2021-11-17 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
|
|
7S8N
| CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | Descriptor: | (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | Deposit date: | 2021-09-18 | Release date: | 2021-11-17 | Last modified: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
|
|
7S8P
| CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | Deposit date: | 2021-09-18 | Release date: | 2021-11-17 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
|
|
6K3K
| Solution structure of APOBEC3G-CD2 with ssDNA, Product B | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3G, DNA/RNA (5'-D(*AP*TP*TP*CP*UP*(ICY)P*AP*AP*TP*T)-3'), ZINC ION | Authors: | Cao, C, Yan, X, Lan, W, Wang, C. | Deposit date: | 2019-05-19 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. Chem Asian J, 14, 2019
|
|
6K3J
| Solution structure of APOBEC3G-CD2 with ssDNA, Product A | Descriptor: | DNA (5'-D(*AP*TP*TP*CP*UP*(IUR)P*AP*AP*TP*T)-3'), DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION | Authors: | Cao, C, Yan, X, Lan, W, Wang, C. | Deposit date: | 2019-05-19 | Release date: | 2019-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA. Chem Asian J, 14, 2019
|
|
5ZKP
| Crystal structure of the human platelet-activating factor receptor in complex with SR 27417 | Descriptor: | FLAVIN MONONUCLEOTIDE, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor | Authors: | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | Deposit date: | 2018-03-25 | Release date: | 2018-06-20 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nat. Struct. Mol. Biol., 25, 2018
|
|
5ZKQ
| Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ... | Authors: | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | Deposit date: | 2018-03-25 | Release date: | 2018-06-20 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for signal recognition and transduction by platelet-activating-factor receptor. Nat. Struct. Mol. Biol., 25, 2018
|
|
7D3V
| |
7D3X
| |
7D3W
| |
5J3F
| NMR solution structure of [Rp, Rp]-PT dsDNA | Descriptor: | DNA (5'-D(*CP*GP*(RSG)P*CP*CP*GP*CP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*GP*CP*GP*(RSG)P*CP*CP*G)-3') | Authors: | Lan, W, Hu, Z, Cao, C. | Deposit date: | 2016-03-30 | Release date: | 2016-11-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural investigation into physiological DNA phosphorothioate modification Sci Rep, 6, 2016
|
|
5WPY
| |
5WPX
| |
8DWH
| CryoEM structure of Gq-coupled MRGPRX1 with ligand Compound-16 | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
|
|
8DWG
| CryoEM structure of Gq-coupled MRGPRX1 with peptide ligand BAM8-22 and positive allosteric modulator ML382 | Descriptor: | 2-[(cyclopropanesulfonyl)amino]-N-(2-ethoxyphenyl)benzamide, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
|
|
8DWC
| CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 | Descriptor: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liu, Y, Cao, C, Fay, J.F, Roth, B.L. | Deposit date: | 2022-08-01 | Release date: | 2022-11-02 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19, 2023
|
|
8KFL
| Stable G-quadruplex Conformation Formed in Promoter Region of Oncogene RET in 100 mM Na+ | Descriptor: | DNA (5'-D(*GP*GP*GP*TP*AP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*G)-3') | Authors: | Zhang, Y.P, Lan, W.X, Yin, S.W, Liu, Z.J, Xue, H.J, Cao, C.Y. | Deposit date: | 2023-08-15 | Release date: | 2024-09-04 | Method: | SOLUTION NMR | Cite: | Stable G-quadruplex Conformation Formed in Promoter Region of Oncogene RET Indicates New Target for Anti-cancer Drug Screening To Be Published
|
|
1J0Q
| Solution Structure of Oxidized Bovine Microsomal Cytochrome b5 mutant V61H | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, cytochrome b5 | Authors: | Wu, H, Huang, Z, Cao, C, Zhang, Q, Wang, Y.-H, Ma, J.-B, Xue, L.-L. | Deposit date: | 2002-11-20 | Release date: | 2003-08-12 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | The solution structure of the oxidized bovine microsomal cytochrome b5 mutant V61H Biochem.Biophys.Res.Commun., 307, 2003
|
|
1G7R
| X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B | Descriptor: | TRANSLATION INITIATION FACTOR IF2/EIF5B | Authors: | Roll-Mecak, A, Cao, C, Dever, T.E, Burley, S.K. | Deposit date: | 2000-11-14 | Release date: | 2000-12-06 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding. Cell(Cambridge,Mass.), 103, 2000
|
|
5WTU
| |
1NKU
| |