8DWC

CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22

Summary for 8DWC

Entry DOI	10.2210/pdb8dwc/pdb
EMDB information	27752
Descriptor	Proenkephalin-A, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	gpcr, signaling protein
Biological source	Bos taurus (cattle) More
Total number of polymer chains	6
Total formula weight	139357.82
Authors	Liu, Y.,Cao, C.,Fay, J.F.,Roth, B.L. (deposition date: 2022-08-01, release date: 2022-11-02, Last modification date: 2023-04-12)
Primary citation	Liu, Y.,Cao, C.,Huang, X.P.,Gumpper, R.H.,Rachman, M.M.,Shih, S.L.,Krumm, B.E.,Zhang, S.,Shoichet, B.K.,Fay, J.F.,Roth, B.L. Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nat.Chem.Biol., 19:416-422, 2023 Cited by PubMed: 36302898 DOI: 10.1038/s41589-022-01173-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.87 Å)

Structure validation