8YRG

CryoEM structure of fospropofol-bound MRGPRX4-Gq complex

This is a non-PDB format compatible entry.

Summary for 8YRG

• Entry DOI: 10.2210/pdb8yrg/pdb
• EMDB information: 39542
• Descriptor: Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr-g protein complex, signaling protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 157717.28

Authors

Cao, C.,Fay, J.F.,Roth, B.L. (deposition date: 2024-03-21, release date: 2024-05-22)

• Primary citation: Chien, D.C.,Limjunyawong, N.,Cao, C.,Meixiong, J.,Peng, Q.,Ho, C.Y.,Fay, J.F.,Roth, B.L.,Dong, X.; MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.; Sci Transl Med, 16:eadk8198-eadk8198, 2024; PubMed: 38718132; DOI: 10.1126/scitranslmed.adk8198

Experimental method

ELECTRON MICROSCOPY (3.14 Å)