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PDB: 64 results

7KNT
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CryoEM structure of the apo-CGRP receptor in a detergent micelle
Descriptor: Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1
Authors:Belousoff, M.J, Danev, R.
Deposit date:2020-11-06
Release date:2021-02-24
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.
Science, 372, 2021
7LCI
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BU of 7lci by Molmil
PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M.
Deposit date:2021-01-11
Release date:2021-01-20
Last modified:2021-09-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Evolving cryo-EM structural approaches for GPCR drug discovery.
Structure, 29, 2021
7LCJ
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PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor
Authors:Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M.
Deposit date:2021-01-11
Release date:2021-01-20
Last modified:2021-09-15
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Evolving cryo-EM structural approaches for GPCR drug discovery.
Structure, 29, 2021
7LCK
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PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R)
Descriptor: 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor
Authors:Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M.
Deposit date:2021-01-11
Release date:2021-01-20
Last modified:2021-09-15
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Evolving cryo-EM structural approaches for GPCR drug discovery.
Structure, 29, 2021
9AUC
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BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-02-28
Release date:2024-04-24
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
9BKJ
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BU of 9bkj by Molmil
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
Descriptor: AMINO GROUP, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Cary, B.P, Harikumar, K.G, Zhao, P, Desai, A.J, Mobbs, J.M, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
To Be Published
9BKK
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Cholecystokinin 1 receptor (CCK1R) sterol 7M mutant, Gq chimera (mGsqi) complex
Descriptor: Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Harikumar, K.G, Zhao, P, Cary, B.P, Xu, X, Desai, A.J, Mobbs, J.I, Toufaily, C, Furness, S.G.B, Christopoulos, A, Belousoff, M.J, Wootten, D, Sexton, P.M, Miller, L.J.
Deposit date:2024-04-29
Release date:2024-05-22
Method:ELECTRON MICROSCOPY (2.51 Å)
Cite:Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
To Be Published
8U8F
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BU of 8u8f by Molmil
GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs.
Descriptor: G-protein coupled receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Russell, I.C, Belousoff, M.J, Sexton, P.
Deposit date:2023-09-17
Release date:2024-03-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3.
Biochemistry, 63, 2024
7MBY
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BU of 7mby by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gq chimera (mGsqi) complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (2.44 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
7MBX
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BU of 7mbx by Molmil
Human Cholecystokinin 1 receptor (CCK1R) Gs complex
Descriptor: CHOLESTEROL HEMISUCCINATE, Cholecystokinin receptor type A, Cholecystokinin-8, ...
Authors:Mobbs, J.I, Belousoff, M.J, Danev, R, Thal, D.M, Sexton, P.M.
Deposit date:2021-04-01
Release date:2021-05-26
Last modified:2021-07-14
Method:ELECTRON MICROSCOPY (1.95 Å)
Cite:Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Plos Biol., 19, 2021
5W68
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BU of 5w68 by Molmil
Type II secretin from Enteropathogenic Escherichia coli - GspD
Descriptor: Putative type II secretion protein
Authors:Hay, I.D, Belousoff, M.J, Dunstan, R, Bamert, R, Lithgow, T.
Deposit date:2017-06-16
Release date:2017-11-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structure and Membrane Topography of the Vibrio-Type Secretin Complex from the Type 2 Secretion System of Enteropathogenic Escherichia coli.
J. Bacteriol., 200, 2018
5WLN
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BU of 5wln by Molmil
Cryo-EM structure of the T2SS secretin XcpQ from Pseudomonas aeruginosa
Descriptor: Type II secretion system protein D
Authors:Hay, I.D, Belousoff, M.J, Lithgow, T.J.
Deposit date:2017-07-27
Release date:2017-10-25
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural Basis of Type 2 Secretion System Engagement between the Inner and Outer Bacterial Membranes.
MBio, 8, 2017
8FLR
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BU of 8flr by Molmil
Human PTH1R in complex with PTHrP and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLQ
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BU of 8flq by Molmil
Human PTH1R in complex with PTH(1-34) and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLS
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BU of 8fls by Molmil
Human PTH1R in complex with Abaloparatide and Gs
Descriptor: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLT
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BU of 8flt by Molmil
Human PTH1R in complex with M-PTH(1-14) and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLU
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BU of 8flu by Molmil
Human PTH1R in complex with LA-PTH and Gs
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
Deposit date:2022-12-22
Release date:2023-04-26
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
7LLY
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BU of 7lly by Molmil
Oxyntomodulin-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
Descriptor: Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H.
Deposit date:2021-02-04
Release date:2022-01-12
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Nat Commun, 13, 2022
7LLL
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BU of 7lll by Molmil
Exendin-4-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in complex with Gs protein
Descriptor: Exendin-4, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wootten, D, Sexton, P.M, Belousoff, M.J, Danev, R, Zhang, X, Khoshouei, M, Venugopal, H.
Deposit date:2021-02-04
Release date:2022-01-12
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
Nat Commun, 13, 2022
8F0J
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BU of 8f0j by Molmil
Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-03
Release date:2023-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
8F2B
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BU of 8f2b by Molmil
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J.
Deposit date:2022-11-07
Release date:2023-08-02
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2 Å)
Cite:Structural insight into selectivity of amylin and calcitonin receptor agonists.
Nat.Chem.Biol., 20, 2024
6WZG
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BU of 6wzg by Molmil
Human secretin receptor Gs complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J, Belousoff, M.J, Danev, R.
Deposit date:2020-05-13
Release date:2020-08-12
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
7TYW
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BU of 7tyw by Molmil
Human Amylin1 Receptor in complex with Gs and salmon calcitonin peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin receptor, ...
Authors:Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
Deposit date:2022-02-14
Release date:2022-03-23
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TZF
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BU of 7tzf by Molmil
Human Amylin3 Receptor in complex with Gs and rat amylin peptide
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
Deposit date:2022-02-15
Release date:2022-03-23
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:A structural basis for amylin receptor phenotype.
Science, 375, 2022
7TYF
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BU of 7tyf by Molmil
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
Descriptor: (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M.
Deposit date:2022-02-13
Release date:2022-03-23
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:A structural basis for amylin receptor phenotype.
Science, 375, 2022

221051

數據於2024-06-12公開中

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